UniProt Accession

 YKT6_MOUSE; Q9CQW1; O88595 

Genbank Protein ID

 AF076956; AK002916; AK007486; AK147098; AK150472; AK159253; AL645469; BC006760 

Genbank Nucleotide ID

 AAC26834.1; BAB22455.1; BAB25062.1; BAE27674.1; BAE29589.1; BAE34934.1; CAI25267.1; AAH06760.1 

Protein Name

 Synaptobrevin homolog YKT6 

Protein Synonyms/Alias

  

Gene Name

 Ykt6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	YSLSVLYKGDPKAVL	acetylation	[1]
15	VLYKGDPKAVLLKAA	acetylation	[1]
60	KGSRASVKEQEYLCH	acetylation	[1]
96	VAFTLLEKVLDEFSK	acetylation	[1]
103	KVLDEFSKQVDRIDW	acetylation	[1]
103	KVLDEFSKQVDRIDW	ubiquitination	[2]
150	QAELDETKIILHNTM	acetylation	[1]
166	SLLERGEKLDDLVSK	ubiquitination	[2]
182	EVLGTQSKAFYKTAR	acetylation	[1]
182	EVLGTQSKAFYKTAR	ubiquitination	[2]
186	TQSKAFYKTARKQNS	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (By similarity). 

Sequence Annotation

 DOMAIN 8 131 Longin.
 DOMAIN 138 198 v-SNARE coiled-coil homology.
 MOD_RES 195 195 Cysteine methyl ester (By similarity).
 LIPID 194 194 S-palmitoyl cysteine (By similarity).
 LIPID 195 195 S-farnesyl cysteine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Lipoprotein; Membrane; Methylation; Palmitate; Prenylation; Protein transport; Reference proteome; Transferase; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; ISS:HGNC.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; ISS:HGNC.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0019706; F:protein-cysteine S-palmitoleyltransferase activity; ISS:HGNC.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:HGNC.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Compara.
 GO:0006904; P:vesicle docking involved in exocytosis; ISS:HGNC.
 GO:0006903; P:vesicle targeting; ISS:HGNC. 

Interpro

 IPR011012; Longin-like_dom.
 IPR010908; Longin_dom.
 IPR001388; Synaptobrevin. 

Pfam

 PF13774; Longin
 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS50859; LONGIN
 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS