CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027464
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 2 
Protein Synonyms/Alias
  
Gene Name
 PF14_0486 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
419EKTDLYEKNIQRTVLacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 832 AA 
Protein Sequence
MVNFTVDQVR EIMNKTKQIR NMSVIAHVDH GKSTLTDSLV SKAGIISSKN AGDARFTDTR 60
QDEQERCITI KSTGISMYFE HDLEDGEGKK PFLINLIDSP GHVDFSSEVT AALRVTDGAL 120
VVVDTIEGVC VQTETVLYQA LGERIKPVLH VNKVDRALLE LQMEVEDIYQ TFARTIESVN 180
VIISTYTDKL MGDIQVYPEK GTVSFGSGLQ GWAFTLETFS RIYSKKFGIE KKKMMQRLWG 240
NSFYDAKTKK WSKNQQEGYK RGFCQFIMEP ILNLCQSIMN DDKEKYTKML TNIGVELKGD 300
DKLLTGKQLL KKAMQLWLPA GDTLLEMIVT HLPSPADAQK YRVENLYEGP MDDEAANAIR 360
NCDPNGPLMM YISKMVPTSD KGRFYAFGRV FSGTVATGQK VRIQGPHYVP GEKTDLYEKN 420
IQRTVLMMGR YTEQVQDVPC GNTCCLVGVD QYIVKSGTIT TFKEAHNIAD MKYSVSPVVR 480
VAVKPKDSKQ LPKLVDGLKK LAKSDPLVLC TTDESGEHII SGCGELHIEI CLKDLKDEYA 540
QIDFIVSDPV VSYRETVTEE STITCLGKSP NKHNRLFMKA YPLAEGLPEA IDKNKVSDKD 600
DPKTRANYLH SNFQWDKNLA LKIWAFGPET IGPNLLTDNT SGIQYMNEIK VHCVAAFQWA 660
SKEGVLCEEN MRGIEFRMLD VHMHADAIHR GAGQIMPACK KCIYACELTA FPRLVEPIYL 720
VDISCPQDVV SGVYGVLNKR RGIVISEEQK LGTPLLKIQS HLPVSESFGF TSALRAATSG 780
QAFPQCVFDH WSVLYDDPFD SNKNSYKIIM NIRERKGIKV EMPQLDQYLD KL 832 
Gene Ontology
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR009022; EFG_III-V.
 IPR000640; EFG_V.
 IPR027417; P-loop_NTPase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
 IPR005225; Small_GTP-bd_dom.
 IPR005517; Transl_elong_EFG/EF2_IV.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00679; EFG_C
 PF03764; EFG_IV
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2 
SMART
 SM00838; EFG_C
 SM00889; EFG_IV 
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.