CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044629
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bardet-Biedl syndrome 2 protein 
Protein Synonyms/Alias
  
Gene Name
 BBS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20ELRKVLVKVDEYHSVubiquitination[1]
30EYHSVHQKLSADMADubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 142 AA 
Protein Sequence
LQVEADFPVY FEELRKVLVK VDEYHSVHQK LSADMADHSN LIRSLLVGAE DARLMRDMKT 60
MKSRYMELYD LNRDLLNGYK IRCNNHTELL GNLKAVNQAI QRAGRLRVGK PKNQVITACR 120
DAIRSNNINT LFKIMRVGTA SS 142 
Gene Ontology
 GO:0034464; C:BBSome; IEA:Compara.
 GO:0031514; C:motile cilium; IEA:Compara.
 GO:0030534; P:adult behavior; IEA:Compara.
 GO:0048854; P:brain morphogenesis; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0038108; P:negative regulation of appetite by leptin-mediated signaling pathway; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; IEA:Compara.
 GO:0045494; P:photoreceptor cell maintenance; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0033365; P:protein localization to organelle; IEA:Compara.
 GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IEA:Compara.
 GO:0007288; P:sperm axoneme assembly; IEA:Compara.
 GO:0021756; P:striatum development; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS