UniProt Accession

 TSYL2_HUMAN; Q9H2G4; O94799; Q96DG7; Q9BZW6 

Genbank Protein ID

 AF273046; AY040871; AL713652; BX322635; BC001566; BC024270; AF254794; AB015345 

Genbank Nucleotide ID

 AAG34906.1; AAK72407.1; CAD28461.1; CAI42531.1; AAH01566.1; AAH24270.1; AAG53596.1; BAA34802.1 

Protein Name

 Testis-specific Y-encoded-like protein 2 

Protein Synonyms/Alias

 TSPY-like protein 2; Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79 

Gene Name

 TSPYL2 

Gene Synonyms/Alias

 CDA1; DENTT; TSPX; HRIHFB2216 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
384	DRIAEIIKNDLWVNP	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. 

Sequence Annotation

 MOD_RES 18 18 Phosphoserine.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 340 340 Phosphothreonine (Probable).  

Keyword

 Cell cycle; Chromatin regulator; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 693 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0000182; F:rDNA binding; NAS:UniProtKB.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0045786; P:negative regulation of cell cycle; NAS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0008156; P:negative regulation of DNA replication; IDA:UniProtKB.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0009966; P:regulation of signal transduction; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002164; NAP_family. 

Pfam

 PF00956; NAP 

SMART

  

PROSITE

  

PRINTS