CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001402
UniProt Accession
Genbank Protein ID
 Y16563 
Genbank Nucleotide ID
Protein Name
 Protein bassoon 
Protein Synonyms/Alias
  
Gene Name
 Bsn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
664EAEEPVPKPYSQDLSubiquitination[1]
3363RKQGMEQKISKFSPIubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity). 
Sequence Annotation
 REPEAT 568 574 1.
 REPEAT 575 581 2.
 REPEAT 582 588 3.
 ZN_FING 167 190 C4-type (Potential).
 ZN_FING 195 217 C4-type (Potential).
 ZN_FING 462 485 C4-type (Potential).
 ZN_FING 490 512 C4-type (Potential).
 REGION 62 70 4 X 2 AA tandem repeats of P-G.
 REGION 568 588 3 X 7 AA tandem repeats of K-A-S-P-Q-A-
 REGION 2934 2996 Sufficient for binding to ERC2.
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 142 142 Phosphoserine (By similarity).
 MOD_RES 965 965 Phosphoserine (By similarity).
 MOD_RES 1004 1004 Phosphoserine (By similarity).
 MOD_RES 1087 1087 Phosphothreonine (By similarity).
 MOD_RES 1090 1090 Phosphoserine (By similarity).
 MOD_RES 1093 1093 Phosphoserine (By similarity).
 MOD_RES 1099 1099 Phosphoserine (By similarity).
 MOD_RES 1101 1101 Phosphothreonine (By similarity).
 MOD_RES 1121 1121 Phosphotyrosine (By similarity).
 MOD_RES 1221 1221 Phosphoserine (By similarity).
 MOD_RES 1469 1469 Phosphoserine (By similarity).
 MOD_RES 1470 1470 Phosphoserine (By similarity).
 MOD_RES 1474 1474 Phosphoserine (By similarity).
 MOD_RES 1481 1481 Phosphoserine (By similarity).
 MOD_RES 1483 1483 Phosphothreonine (By similarity).
 MOD_RES 1485 1485 Phosphoserine (By similarity).
 MOD_RES 1498 1498 Phosphoserine (By similarity).
 MOD_RES 1541 1541 Phosphoserine (By similarity).
 MOD_RES 1542 1542 Phosphoserine (By similarity).
 MOD_RES 2017 2017 Phosphoserine (By similarity).
 MOD_RES 2032 2032 Phosphotyrosine (By similarity).
 MOD_RES 2061 2061 Phosphotyrosine (By similarity).
 MOD_RES 2112 2112 Phosphoserine (By similarity).
 MOD_RES 2564 2564 Phosphoserine (By similarity).
 MOD_RES 2581 2581 Phosphothreonine (By similarity).
 MOD_RES 2608 2608 Phosphothreonine (By similarity).
 MOD_RES 2679 2679 Phosphoserine (By similarity).
 MOD_RES 2688 2688 Phosphothreonine (By similarity).
 MOD_RES 2793 2793 Phosphoserine (By similarity).
 MOD_RES 2796 2796 Phosphoserine (By similarity).
 MOD_RES 2807 2807 Phosphoserine (By similarity).
 MOD_RES 2843 2843 Phosphoserine (By similarity).
 MOD_RES 2845 2845 Phosphoserine (By similarity).
 MOD_RES 2851 2851 Phosphoserine (By similarity).
 MOD_RES 2893 2893 Phosphoserine (By similarity).
 MOD_RES 3007 3007 Phosphoserine (By similarity).
 MOD_RES 3286 3286 Phosphoserine (By similarity).
 MOD_RES 3368 3368 Phosphoserine (By similarity).
 MOD_RES 3417 3417 Phosphotyrosine (By similarity).
 MOD_RES 3418 3418 Phosphotyrosine (By similarity).
 MOD_RES 3445 3445 Phosphotyrosine (By similarity).
 LIPID 2 2 N-myristoyl glycine.
 CARBOHYD 1339 1339 O-linked (GlcNAc).
 CARBOHYD 1380 1380 O-linked (GlcNAc) (By similarity).
 CARBOHYD 1922 1922 O-linked (GlcNAc) (By similarity).
 CARBOHYD 2307 2307 O-linked (GlcNAc) (By similarity).
 CARBOHYD 2510 2510 O-linked (GlcNAc) (By similarity).
 CARBOHYD 2685 2685 O-linked (GlcNAc) (By similarity).
 CARBOHYD 2930 2930 O-linked (GlcNAc) (By similarity).  
Keyword
 Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Lipoprotein; Metal-binding; Myristate; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3938 AA 
Protein Sequence
MGNEASLEGG AGEGPLPPGG SGLGPGPGAG KPPSALAGGG QLPVAGAARA AGPPTPGLGL 60
VPGPGPGPGP GSVSRRLDPK EPLGSQRATS PTPKQASATA PGRESPRETR AQGLSGQEAE 120
GPRRTLQVDS RTQRSGRSPS VSPDRGSTPT SPYSVPQIAP LPSSTLCPIC KTSDLTSTSS 180
QPNFNTCTQC HNKVCNQCGF NPNPHLTQVK EWLCLNCQMQ RALGMDMTTA PRSKSQQQLH 240
SPALSPAHSP AKQPLGKPEQ ERSRSPGATQ SGPRQAEAAR ATSVPGPTQA TAPPEVGRVS 300
PQPPLSTKPS TAEPRPPAGE AQGKSATTVP SGLGAAEQTQ GGLTGKLFGL GASLLTQAST 360
LMSVQPEADT QGQPSPSKGP PKIVFSDASK EAGPRPPGSG PGPGPTPGAK TEPGPRTGPG 420
SGPGALAKTG GTPSPKHGRA DHQAASKAAA KPKTMPKERA ACPLCQAELN VGSRGPANYN 480
TCTACKLRVC TLCGFNPTPH LVEKTEWLCL NCQTKRLLEG SLGEPAPLPL PTPQEPPAGV 540
PQRAAGASPL KQKGPQGPGQ PSGSLPPKAS PQAAKASPQA AKASPQAKPL RASEPSKTSS 600
SAPEKKTGIP VKAEPVPKPP PETAVPPGTP KAKSGVKRTD PATPVVKPVP EAPKSGEAEE 660
PVPKPYSQDL SRSPQSLSDT GYSSDGVSSS QSEITGVVQQ EVEQLDSAGV TGPRPPSPSE 720
LHKVGSSMRP SLEAQAVAPS GEWSKPPSGS AVEDQKRRPH SLSIMPEAFD SDEELGDILE 780
EDDSLAMGRQ REQQDTAESS DDFGSQLRHD YVEDSSEGGL SPLPPQPPAR ADMTDEEFMR 840
RQILEMSAEE DNLEEDDTAV SGRGLAKHGA QKASARPRPE SSQESVALPK RRLPHNATTG 900
YEELLSEEGP AEPTDGALQG GLRRFKTIGL NSTGRLWSTS LDLGQGSDPN LDREPELEME 960
SLTGSPEDRS RGEHSSTLPA STPSYTSGTS PTSLSSLEED SDSSPSRRQR LEEAKQQRKA 1020
RHRSHGPLLP TIEDSSEEEE LREEEELLRE QEKMREVEQQ RIRSTARKTR RDKEELRAQR 1080
RRERSKTPPS NLSPIEDASP TEELRQAAEM EELHRSSCSE YSPSPSLDSE AETLDGGPTR 1140
LYKSGSEYNL PAFMSLCSPT ETPSGSSTTP SSGRPLKSAE EAYEDMMRKA ELLQRQQGQA 1200
AGARGPHGGP SQPTGPRSQG SFEYQDTLDH DYGGRASQPA ADGTPAGLGA TVYEEILQTS 1260
QSIARMRQAS SRDLAFTEDK KKEKQFLNAE SAYMDPMKQN GGPLTPGTSP TQLAAPVSFP 1320
TSTSSDSSGG RVIPDVRVTQ HFAKEPQEPL KLHSSPASPS LASKEVGMTF SQGPGTPATT 1380
AMAPCPASLP RGYMTPAGPE RSPSTSSTIH SYGQPPTTAN YGSQTEELPH APSGPAGSGR 1440
ASREKPLSGG DGEVGPPQPS RGYSYFTGSS PPLSPSTPSE SPTFSPSKLG PRATAEFSTQ 1500
TPSLTPSSDI PRSVGTPSPM VAQGTQTPHR PSTPRLVWQQ SSQEAPVMVI TLASDASSQT 1560
RMVHASASTS PLCSPTDSQP ASHSYSQTTP PSASQMPSEP AGPPGFPRAP SAGVDGPLAL 1620
YGWGALPAEN ISLCRISSVP GTSRVEPGPR PPGTAVVDLR TAVKPTPIIL TDQGMDLTSL 1680
AVEARKYGLA LDPVPGRQST AVQPLVINLN AQEQTHTFLA TATTVSITMA SSVLMAQQKQ 1740
PVVYGDPFQS RLDFGQGSGS PVCLAQVKQV EQAVQTAPYR GGPRGRPREA KFARYNLPNQ 1800
VTPLARRDIL ITQMGTAQSV SLKPGPVPEP GAEPHRATPA ELRAHALPGT RKPHTVVVQM 1860
GEGAAGTVTT LLPEEPAGAL DLTGMRPESR LACCDMAYKF PFGSSCTGTF HPAPSAPDKS 1920
VTDAALPGQS SGPFYSPRDP EPPEPLTFRA QGVVGPGPHE EQRPYPQGLP GRLYSSMSDT 1980
NLAEAGLNYH AQRIGQLFQG PGRDSAVDLS SLKHSYSLGF ADGRYLGQGL QYGSFTDLRH 2040
PTDLLSHPLP MRPYSSVSNI YSDHRYGPRG DAVGFQEASL AQYSATTARE ISRMCAALNS 2100
MDQYGGRHGG GSGGPDLVPY QPQHGPGLNA PQGLASLRSG LLGNPTYPEG QPSPGNLAQY 2160
GPAASQGTAV RQLLPSTATV RAADGMIYST INTPIAATLP ITTQPASVLR PMVRGGMYRP 2220
YGSGGVTAVP LTSLTRVPMI APRVPLGPAG LYRYPAPSRF PIASTIPPAE GPVYLGKPAA 2280
AKASGAGGPP RPELPAGGAR EEPLSTTAPP AVIKEAPVAQ APAPPPGQKP AGDAAAGSGS 2340
GVLGRPVMEK EEASQEDRQR KQQEQLLQLE RERVELEKLR QLRLQEELER ERVELQRHRE 2400
EEQLLVQREL QELQTIKHHV LQQQQEERQA QFALQREQLA QQRLQLEQIQ QLQQQLQQQL 2460
EEQKQRQKAP FPATCEAPSR GPPPAATELA QNGQYWPPLT HTAFIAVAGT EGPGQAREPV 2520
LHRGLPSSAS DMSLQTEEQW EAGRSGIKKR HSMPRLRDAC EPESGPDPST VRRIADSSVQ 2580
TDDEEGEGRY LLTRRRRTRR SADCSVQTDD EDNAEWEQPV RRRRSRLSRH SDSGSDSKHE 2640
ASASSSAAAA AARAMSSVGI QTISDCSVQT EPEQLPRVSP AIHITAATDP KVEIVRYISA 2700
PEKTGRGESL ACQTEPDGQA QGVAGPQLIG PTAISPYLPG IQIVTPGALG RFEKKKPDPL 2760
EIGYQAHLPP ESLSQLVSRQ PPKSPQVLYS PVSPLSPHRL LDTSFASSER LNKAHVSPQK 2820
QFIADSTLRQ QTLPRPMKTL QRSLSDPKPL SPTAEESAKE RFSLYQHQGG LGSQVSALPP 2880
NGLVRKVKRT LPSPPPEEAH LPLAGQVPSQ LYAASLLQRG LAGPTTVPAT KASLLRELDR 2940
DLRLVEHEST KLRKKQAELD EEEKEIDAKL KYLELGITQR KESLAKDRVG RDYPPLRGLG 3000
EHRDYLSDSE LNQLRLQGCT TPAGQYVDYP ASAAVPATPS GPTAFQQPRF PPAATQYTAG 3060
SSGPTQNGFL AHQAPTYTGP STYPAPTYPP GTSYPAEPGL PSQPAFHPTG HYAAPTPMPT 3120
TQSAPFPVQA DSHAAHQKPR QTSLADLEQK VPTNYEVISS PAVTVSSTPS ETGYSGPAVS 3180
SSYEHGKAPE HPRGGDRSSV SQSPAPTYPS DSHYTSLEQN VPRNYVMIDD ISELTKDSTP 3240
TASDSQRPEP LGPGGVSGRP GKDPGEPAVL EGPTLPCCYG RGEEESEEDS YDPRGKSGHH 3300
RSMESNGRPA STHYYSDSDY RHGARADKYG PGPMGPKHPS KNLAPAAISS KRSKHRKQGM 3360
EQKISKFSPI EEAKDVESDL ASYPPPTVSS SLTSRSRKFQ DEITYGLKKN VYEQQRYYGV 3420
SSRDTAEEDD RMYGGSSRSR VASAYSGEKL SSHDFSSRSK GYERERETAQ RLQKAGPKPS 3480
SLSMAHGRAR PPMRSQASEE ESPVSPLGRP RPAGGALPPG DTCPQFCSSH SMPDVQEHVK 3540
DGPRAHAYKR EEGYILDDSH CVVSDSEAYH LGQEETDWFD KPRDARSDRF RHHGGHTVSS 3600
SQKRGPARHS YHDYDEPPEE GLWPHDEGGP GRHTSAKEHR HHGDHGRHSG RHAGEEPGRR 3660
AARPHARDMG RHETRPHPQA SPAPAMQKKG QPGYPSSADY SQPSRAPSAY HHASDSKKGS 3720
RQAHSGPTVL QPKPEAQAQP QMQGRQAVPG PQQSQPPSSR QTPSGTASRQ PQTQQQQQQQ 3780
QQQQQQQQQQ QQQQQQQGLG QQAPQQAPSQ ARLQQQSQPT TRSTAPAASH PAGKPQPGPT 3840
TAPGPQPAGL PRAEQAGSSK PAAKAPQQGR APQAQSAPGP AGAKTGARPG GTPGAPAGQP 3900
AAEGESVFSK ILPGGAAEQA GKLTEAVSAF GKKFSSFW 3938 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0060076; C:excitatory synapse; IDA:BHF-UCL.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; NAS:RGD. 
Interpro
 IPR011011; Znf_FYVE_PHD.
 IPR008899; Znf_piccolo.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF05715; zf-piccolo 
SMART
  
PROSITE
  
PRINTS