UniProt Accession

 PAHX_RAT; P57093; Q9QY64 

Genbank Protein ID

 AF121345; BC086573 

Genbank Nucleotide ID

 AAF15971.1; AAH86573.1 

Protein Name

 Phytanoyl-CoA dioxygenase, peroxisomal 

Protein Synonyms/Alias

 Phytanic acid oxidase; Phytanoyl-CoA alpha-hydroxylase; PhyH 

Gene Name

 Phyh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	PPGMTVMKDVAIAKQ	acetylation	[1]
120	PSERVVTKIQDFQQN	acetylation	[1]
224	LKPHDYPKWEGGVNK	acetylation	[1]
231	KWEGGVNKMYHGIQD	acetylation	[1]
310	EVIEIAEKRYGVQGA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. 

Sequence Annotation

 REGION 175 177 Alpha-ketoglutarate binding (By
 METAL 175 175 Iron (By similarity).
 METAL 177 177 Iron (By similarity).
 METAL 264 264 Iron (By similarity).
 BINDING 120 120 Alpha-ketoglutarate (By similarity).
 BINDING 157 157 Alpha-ketoglutarate (By similarity).
 BINDING 193 193 Alpha-ketoglutarate (By similarity).
 BINDING 266 266 Alpha-ketoglutarate (By similarity).
 BINDING 275 275 Alpha-ketoglutarate (By similarity).  

Keyword

 Complete proteome; Dioxygenase; Direct protein sequencing; Iron; Metal-binding; Oxidoreductase; Peroxisome; Reference proteome; Transit peptide; Vitamin C. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0048037; F:cofactor binding; IEA:Compara.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0048244; F:phytanoyl-CoA dioxygenase activity; IDA:RGD.
 GO:0001561; P:fatty acid alpha-oxidation; TAS:RGD.
 GO:0006720; P:isoprenoid metabolic process; IEA:Compara.
 GO:0097089; P:methyl-branched fatty acid metabolic process; IEA:Compara. 

Interpro

 IPR008775; Phytyl_CoA_dOase. 

Pfam

 PF05721; PhyH 

SMART

  

PROSITE

  

PRINTS