CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FERM, RhoGEF and pleckstrin domain-containing protein 1 
Protein Synonyms/Alias
 Chondrocyte-derived ezrin-like protein; Pleckstrin homology domain-containing family C member 2; PH domain-containing family C member 2 
Gene Name
 FARP1 
Gene Synonyms/Alias
 CDEP; PLEKHC2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
456EEEEEVVKDRTQQSKubiquitination[1]
572WFQSTVSKEDAMPEAubiquitination[1]
1071RPHVLSHKESLVY**ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). 
Sequence Annotation
 DOMAIN 40 320 FERM.
 DOMAIN 540 730 DH.
 DOMAIN 759 856 PH 1.
 DOMAIN 932 1029 PH 2.
 MOD_RES 24 24 Phosphothreonine.
 MOD_RES 340 340 Phosphoserine.
 MOD_RES 427 427 Phosphoserine.
 MOD_RES 510 510 Phosphoserine.
 MOD_RES 514 514 Phosphoserine.
 MOD_RES 872 872 Phosphoserine.
 MOD_RES 889 889 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Developmental protein; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Synapse; Synaptosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1045 AA 
Protein Sequence
MGEIEQRPTP GSRLGAPENS GISTLERGQK PPPTPSGKLV SIKIQMLDDT QEAFEVPQRA 60
PGKVLLDAVC NHLNLVEGDY FGLEFPDHKK ITVWLDLLKP IVKQIRRPKH VVVKFVVKFF 120
PPDHTQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL 180
AKNKYIPQQD ALEDKIVEFH HNHIGQTPAE SDFQLLEIAR RLEMYGIRLH PAKDREGTKI 240
NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDANSAYQD TLEFLMASRD 300
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ 360
FERKHSKIHS IRSLASQPTE LNSEVLEQSQ QSTSLTFGEG AESPGGQSCR RGKEPKVSAG 420
EPGSHPSPAP RRSPAGNKQA DGAASAPTEE EEEVVKDRTQ QSKPQPPQPS TGSLTGSPHL 480
SELSVNSQGG VAPANVTLSP NLSPDTKQAS PLISPLLNDQ ACPRTDDEDE GRRKRFPTDK 540
AYFIAKEVST TERTYLKDLE VITSWFQSTV SKEDAMPEAL KSLIFPNFEP LHKFHTNFLK 600
EIEQRLALWE GRSNAQIRDY QRIGDVMLKN IQGMKHLAAH LWKHSEALEA LENGIKSSRR 660
LENFCRDFEL QKVCYLPLNT FLLRPLHRLM HYKQVLERLC KHHPPSHADF RDCRAALAEI 720
TEMVAQLHGT MIKMENFQKL HELKKDLIGI DNLVVPGRPG SFSLMRTPHL GQARRIPCAP 780
ERRPLLLVKE FIRLGSLSKL SGKGLQQRMF FLFNDVLLYT SRGLTASNQF KVHGQLPLYG 840
MTIEESEDEW GVPHCLTLRG QRQSIIVAAS SRSEMEKWVE DIQMAIDLAE KSSSPAPEFL 900
ASSPPDNKSP DEATAADQES EDDLSASRTS LERQAPHRGN TMVHVCWHRN TSVSMVDFSI 960
AVENQLSGNL LRKFKNSNGW QKLWVVFTNF CLFFYKSHQD NHPLASLPLL GYSLTIPSES 1020
ENIQKDYVFK LHFKSHVYYF RAESEYTFER WMEVIRSATS SASRPHVLSH KESLVY 1076 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; TAS:ProtInc.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
 GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007416; P:synapse assembly; ISS:UniProtKB. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000219; DH-domain.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00295; B41
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3
 PS50003; PH_DOMAIN 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.