UniProt Accession

 AROG_ECOLI; P0AB91; P00886 

Genbank Protein ID

 J01591; U00096; AP009048 

Genbank Nucleotide ID

 AAA23492.1; AAC73841.1; BAA35416.1 

Protein Name

 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive 

Protein Synonyms/Alias

 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase 

Gene Name

 aroG 

Gene Synonyms/Alias

 b0754; JW0737 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
11	QNDDLRIKEIKELLP	acetylation	[1]
14	DLRIKEIKELLPPVA	acetylation	[1]
25	PPVALLEKFPATENA	acetylation	[1]
41	NTVAHARKAIHKILK	acetylation	[1]
45	HARKAIHKILKGNDD	acetylation	[1, 2]
48	KAIHKILKGNDDRLL	acetylation	[1, 2]
70	IHDPVAAKEYATRLL	acetylation	[1]
84	LALREELKDELEIVM	acetylation	[1]
186	LSCPVGFKNGTDGTI	acetylation	[1]
194	NGTDGTIKVAIDAIN	acetylation	[1]
237	HIILRGGKEPNYSAK	acetylation	[1, 2]
244	KEPNYSAKHVAEVKE	acetylation	[1, 2, 3]
250	AKHVAEVKEGLNKAG	acetylation	[1]
255	EVKEGLNKAGLPAQV	acetylation	[1]
273	FSHANSSKQFKKQMD	acetylation	[1]
276	ANSSKQFKKQMDVCA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). 

Sequence Annotation

 MOD_RES 244 244 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:EC.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
 GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR006218; DAHP1/KDSA.
 IPR006219; DHAP_synth_1. 

Pfam

 PF00793; DAHP_synth_1 

SMART

  

PROSITE

  

PRINTS