UniProt Accession

 RHO1_YEAST; P06780; D6W4G6 

Genbank Protein ID

 M15189; U25840; M15161; AY558062; BK006949 

Genbank Nucleotide ID

 AAA34977.1; AAB68152.1; AAA74729.1; AAS56388.1; DAA11582.1 

Protein Name

 GTP-binding protein RHO1 

Protein Synonyms/Alias

 Rho-type GTPase 1 

Gene Name

 RHO1 

Gene Synonyms/Alias

 YPR165W; P9325.3 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
167	GYYECSAKTGYGVRE	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7. 

Sequence Annotation

 NP_BIND 17 24 GTP (By similarity).
 NP_BIND 64 68 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 MOTIF 39 47 Effector region (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 206 206 Cysteine methyl ester.
 LIPID 206 206 S-geranylgeranyl cysteine.  

Keyword

 3D-structure; Acetylation; Cell membrane; Complete proteome; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Peroxisome; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0000148; C:1,3-beta-D-glucan synthase complex; IDA:SGD.
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0005777; C:peroxisome; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0004871; F:signal transducer activity; TAS:SGD.
 GO:0031532; P:actin cytoskeleton reorganization; IGI:SGD.
 GO:0007117; P:budding cell bud growth; IMP:SGD.
 GO:0045807; P:positive regulation of endocytosis; IMP:SGD.
 GO:0090037; P:positive regulation of protein kinase C signaling cascade; IMP:SGD.
 GO:0008361; P:regulation of cell size; IMP:SGD.
 GO:0060178; P:regulation of exocyst localization; IMP:SGD.
 GO:0070610; P:regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process; IDA:SGD.
 GO:0060237; P:regulation of fungal-type cell wall organization; IMP:SGD.
 GO:0032889; P:regulation of vacuole fusion, non-autophagic; IMP:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IDA:SGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.