Tag | Content |
---|
CPLM ID | CPLM-039041 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ryanodine receptor 2 |
Protein Synonyms/Alias | |
Gene Name | Ryr2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
---|
3168 | IDEGAWMKRLAVFSQ | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4826 AA |
Protein Sequence | MYLCCLSTSR SSTDKLAFDV GLQEDTTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS 60 SERYLHLSYG NSSWRVDAAF QQTLWSVAPI SSGSEAAQGY LIGGDVLRLL HGHMDECLTV 120 PSGEHGEEQR RTVHYEGGAV SVHARSLWRL ETLRVAWSGS HIRWGQPFRL RHVTTGKYLS 180 LMEDKNLLLM DKEKADVKST AFAFRSSKEK LDAGVRKEVD GMGTSEIKYG DSICYIQHVD 240 TGLWLTYQAV DVKSARMGSI QRKAIMHHEG HMDDGLNLSR SQHEESRTAR VIRSTVFLFN 300 RFIRGLDALS KRAKLPTVDL PIESVSLSLQ DLIGYFHPPD EHLEHEDKQN RLRALKNRQN 360 LFQEEGMINL VLECIDRLHV YSSAAHFADV AGREAGESWK SILNSLYELL AALIRGNRKN 420 CAQFSGSLDW LISRLERLEA SSGILEVLHC VLVESPEALN IIKEGHIKSI ISLLDKHGRN 480 HKVLDVLCSL CVCHGVAVRS NQHLICDNLL PGRDLLLQTR LVNHVSSMRP NIFLGVSEGS 540 AQYKKWYYEL MVDHTEPFVT AEATHLRVGW ASTEGYSPYP GGGEEWGGNG VGDDLFSYGF 600 DGLHLWSGCI ARTVSSPNQH LLRTDDVISC CLDLSAPSIS FRINGQPVQG MFENFNIDGL 660 FFPVVSFSAG IKVRFLLGGR HGEFKFLPPP GYAACYEAVL PKEKLKVEHS REYKQERTYT 720 RDLLGPTVSL TQAAFTPVPV DTSQIVLPPH LERIRERLAE NIHELWVMNK IELGWQYGPV 780 RDDNKRQHPC LVEFCKLPEQ ERNYNLQMSL ETLKTLLALG CHVGIADEHA EEKVKKMKLP 840 KNYQLTSGYK PAPMDLSFIK LTPSQEAMVD KLAENAHNVW ARDRIRQGWT YGIQQDVKNR 900 RNPRLVPYTL LDDRTKKSNK DSLREAVRTL LGYGYHLEAP DQDHASRAEV CSGTGERFRI 960 FRAEKTYAVK AGRWYFEFEA VTAGDMRVGW SRPGCQPDLE LGSDERAFAF DGFKAQRWHQ 1020 GNEHYGRSWQ AGDVVGCMVD MNEHTMMFTL NGEILLDDSG SELAFKDFDV GDGFIPVCSL 1080 GVAQVGRMNF GKDVSTLKYF TICGLQEGYE PFAVNTNRDI TMWLSKRLPQ FLQVPSNHEH 1140 IEVTRIDGTI DSSPCLKVTQ KSFGSQNSNT DIMFYRLSMP IECAEVFSKS VAGGIPGAGF 1200 YGPKNDLEDF DVDSDFEVLM KTAHGHLVPD RMDKDKETPK PEFNNHKDYA QEKPSRLKQR 1260 FLLRRTKPDY STSHSARLTE DVLADDRDDY EYLMQTSTYY YSVRIFPGQE PANVWVGWIT 1320 SDFHQYDTGF DLDRVRTVTV TLGDEKGKVH ESIKRSNCYM VCAGESMSPG QGRNNSNGLE 1380 IGCVVDAASG LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL 1440 SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ 1500 FMSLHIPEEN RSVDILELTE QEELLQFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL 1560 YAIENKYMPG LLRAGYYDLL IDIHLSSYAT ARLMMNNEFI VPMTEETKSI TLFPDENKKH 1620 GLPGIGLSTS LRPRMCFSSP SFVSISNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA 1680 RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEEGGAPEK 1740 EISIDDSKLE VKEEAKAGKR PKEGLLQMKL PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF 1800 SDDFVAKLQD NQRFRYNEVM QALNMSAALT ARKTKEFRSP PQEQINMLLN FKDDKSECPC 1860 PEEIRDQLLD FHEDLMTHCG IELDEDGSLD GSNDLTIRGR LLSLVEKVTY LKKKQAEKPV 1920 ASDSRKSSSL QQLISETMVR WAQESVIEDP ELVRAMFVLL HRQYDGIGGL VRALPKTYTI 1980 NGVSVEDTIN LLASLGQIRS LLSVRMGKEE EKLMIRGLGD IMNNKVFYQH PNLMRALGMH 2040 ETVMEVMVNV LGGGESKEIT FPKMVANCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG 2100 LASPAMRGST PLDVAAASVM DNNELALALR EPDLEKVVRY LAGCGLQSCQ MLVSKGYPDI 2160 GWNPVEGERY LDFLRFAVFC NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME 2220 EAIKIAEDPS RDGPSPTSGS SKTLDAEEEE DDTIHMGNAI MTFYAALIDL LGRCAPEMHL 2280 IHAGKGEAIR IRSILRSLIP LGDLVGVISI AFQMPTIAKD GKVVEPDMSA GFCPDHKAAM 2340 VLFLDRVYGI EVQDFLLHLL EVGFLPDLRA AASLDTAALS ATDMALALNR YLCTAVLPLL 2400 TRCAPLFAGT EHHASLIDSL LHTVYRLSKG CSLTKAQRDS IEVCLLSICG QLRPSMMQHL 2460 LRRLVFDVPL LNEHAKMPLK LLTNHYERCW KYYCLPGGWS NFGAASEEEL HLSRKLFWGI 2520 FDALSQKKYE QELFKLALPC LSAVAGALPP DYMESNYVSM MEKQSSMDSE GNFNPQPVDT 2580 SNITIPEKLE YFINKYAEHS HDKWSMDKLA NGWIYGEIYS DSSKIQPLMK PYKLLSEKEK 2640 EIYRWPIKES LKTMLAWGWR IERTREGDSM ALYNRTRRIS QTSQVSIDAA HGYSPRAIDM 2700 SNVTLSRDLH AMAEMMAENY HNIWAKKKKM ELESKGGGNH PLLVPYDTLT AKEKAKDREK 2760 AQDIFKFLQI SGYAVSRGFK DLDLDTPSIE KRFAYSFLQQ LIRYVDEAHQ YILEFDGGSR 2820 SKGEHFPYEQ EIKFFAKVVL PLIDQYFKNH RLYFLSAASR PLCTGGHASN KEKEMVTSLF 2880 CKLGVLVRHR ISLFGNDATS IVNCLHILGQ TLDARTVMKT GLDSVKSALR AFLDNAAEDL 2940 EKTMENLKQG QFTHTRSQPK GVTQIINYTT VALLPMLSSL FEHIGQHQFG EDLILEDVQV 3000 SCYRILTSLY ALGTSKIYVE RQRSALGECL AAFAGAFPIA FLETHLDKHN VYSIYNTRSS 3060 RERAALSLPA NVEDVCPNIP SLEKLMTEII ELAESGIRYT QMPHMMEVVL PMLCSYMSRW 3120 WEHGPENHPE RAEMCCTALN SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL AVFSQPIINK 3180 VKPQLLKTHF LPLMEKLKKK AAMVVSEEDH LKAEARGDMS EAELLILDEF TTLARDLYAF 3240 YPLLIRFVDY NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF VVQNEINNMS 3300 FLITDTKSKM SKAAISDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN ICAPGDQELI 3360 ALAKNRFSLK DTEEEVRDVI RSNIHLQGKL EDPAIRWQMA LYKDLPNRAE DTSDPERTVE 3420 RVLDIANVLF HLEQVEHPQR SKKAVWHKLL SKQRKRAVVA CFRMAPLYNL PRHRAVNLFL 3480 QGYEKSWIET EEHYFEDKLI EDLAKPGSEL PEEDEAMKRV DPLHQLILLF SRTALTEKCK 3540 LEEDFLYMAY ADIMAKSCHD EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL 3600 QTFSASKGET GPMVAATLKL GIAILNGGNS TVQQKMLDYL KEKKDVGFFQ SLAGLMQSCS 3660 VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR FLQLLCEGHN SDFQNYLRTQ 3720 TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDIIDEQ GQRNFSKAIQ VAKQVFNTLT 3780 EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMQMKLSQD SSQIELLKEL MDLQKDMVVM 3840 LLSMLEGNVV NGTIGKQMVD MLVESSNNVE MILKFFDMFL KLKDLTSSDT FKEYDPDGKG 3900 VISKRDFHKA MESHKHYTQS ETEFLLSCAE TDENETLDYE EFVKRFHEPA KDIGFNVAVL 3960 LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS AKRIERVYFE ISESSRTQWE 4020 KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ LAAQISESDL NERSANKEES 4080 EKERPEEQAP RMGFFSLLTV QSALFALRYN VLTLVRMLSL KSLKKQMKRM KKMTVKDMVS 4140 AFFSSYWSVF VTLLHFVASV CRGFFRIVSS LLLGGSLVEG AKKIKVAELL ANMPDPTQDE 4200 VRGDEEEGER KPLESALPSE DLTDLKELTE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG 4260 LSDLMTNPIP VPEVQEKFQE QKVKEEKEGK EETKSEPEKA EGEDGEKEEK AKDDKGKQKL 4320 RQLHTHRYGE PEVPESAFWK KIIAYQQKLL NYFARNFYNM RMLALFVAFA INFILLFYKV 4380 STSSVVEGKE LPTRTSSDAA KVTTSLDSSP HRIIAVHYVL EESSGYMEPT LRILAILHTI 4440 ISFFCIIGYY CLKVPLVIFK REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTQSFP 4500 NNYWDKFVKR KVMDKYGEFY GRDRISELLG MDKAALDFSD AREKKKPKKD SSLSAVLVQV 4560 DLVFQVWLLL STFKDSSFLY LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK TLRTILSSVT 4620 HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT PDMKCDDMLT CYMFHMYVGV 4680 RAGGGIGDEI EDPAGDEYEI YRIIFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK 4740 EDMETKCFIC GIGNDYFDTV PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW 4800 KMYQERCWEF FPAGDCFRKQ YEDQLN 4826 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro. GO:0006874; P:cellular calcium ion homeostasis; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |