| Tag | Content |
|---|
| CPLM ID | CPLM-015517 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lateral signaling target protein 2 homolog |
Protein Synonyms/Alias | Zinc finger FYVE domain-containing protein 28 |
Gene Name | Zfyve28 |
Gene Synonyms/Alias | Kiaa1643; Lst2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 87 | APRDFCVKFPEEIRH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). |
Sequence Annotation | ZN_FING 835 895 FYVE-type.
MOD_RES 888 888 Phosphothreonine; by MAP2K (By
CROSSLNK 87 87 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Complete proteome; Cytoplasm; Endosome; Isopeptide bond; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 905 AA |
Protein Sequence | MMNRFRKWLY KPKRSDPQLL AQFYYADEEL NQVAAELDSL DGRKEPQRCT LLVSQFRSCQ 60
DNVLNIINQI MEECIPQDRA PRDFCVKFPE EIRHDNLAGQ LWFGAECLAA GSIIMNRELE 120
SMAMRPLAKE LTRSLEDVRG TLRDQALRDL NTYTEKMREA LRRFDVLFAE FELSYVSAMV 180
PVKSPREYYV QQEVIVLFCE TVERALDFGY LTQDMIDDYE PALMFTIPRL AIVCGLVVYA 240
DGPLNLDRKV EDMSELFRPF HTLLRKIRDL LQALTEEELH TLERSLCVSQ DVELPIRADT 300
QAPSALAPTF SASLPPEETL SASANNPEAE LACSMQYDDQ ELEELSRMVH RAGDEMSSLL 360
SPPSACQSPA HRPGSEASPR GEASPARARL KSGSDEEERV FFMDDVEVTE SPARPESPGN 420
TFELTQGNAQ QRGQDGQSGE VGVEAPALVK EEDWSNNNVE GDKIKLASLM GSTSCSCLDS 480
QLYLDGWEVS AEDAETAEMI AHRTGGMKLS ATVIFNPKSP TSQDSAVAAQ EAPGHGTSPL 540
EPRAEGTGDN SHKLSTTATN CLLHSCVCCG SCGDSRDDAV ERLREKCGPG SVISASNPSV 600
SLAKGGDKEP ERIDEAQPSD VTLPAEDASN RQEPKAPASS KCLAHTSGPQ VDTASRLQGE 660
GEVKGQPEPE ARKQDPEKSP VVSGDSPRGD VAQTEHQHLL GSSSTVGSCS LDNTRLDVAT 720
AAMPVTPMAT REKIRSRFHG SHDLIHRLFV CISGVADQLQ TNYASDLRSI LKTLFEVMAT 780
KPETDDKEKL KKVTQTLRSA ALEDCALCQE TVSSSELAAK TRDGDFEDPP EWVPDEACGF 840
CTSCKAPFTV IRRKHHCRSC GKIFCSRCSS HSAPLPRYGQ VKPVRVCTHC YMFHVTPFYS 900
DKTGM 905 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0031901; C:early endosome membrane; ISS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |