| Tag | Content |
|---|
| CPLM ID | CPLM-017897 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vam6/Vps39-like protein |
Protein Synonyms/Alias | |
Gene Name | Vps39 |
Gene Synonyms/Alias | Pldn; Vam6 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 204 | KELFPTGKQLEPLVA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF- beta/activin signaling, inhibiting SMAD3- and activating SMAD2- dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3- dependent transcription and relieve SMAD3 inhibition of SMAD2- dependent promoters, thus increasing SMAD2-dependent transcription (By similarity). |
Sequence Annotation | DOMAIN 15 294 CNH.
REPEAT 573 750 CHCR. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Endosome; Lysosome; Membrane; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 886 AA |
Protein Sequence | MHDAFEPVPI LEKLPLQIDC LAAWEEWLLV GTKQGHLLLY RIRKDVVPAD VASPESGSCN 60
RFEVTLEKSN KNFSKKIQQI HVVSQFKILV SLLENNIYVH DLLTFQQITT VSKAKGASLF 120
TCDLQHTETG EEVLRMCVAV RKKLQLYFWK DREFHELQGD FSVPDVPKSM AWCENSICVG 180
FKRDYYLIRV DGKGSIKELF PTGKQLEPLV APLADGKVAV GQDDLTVVLN EEGICTQKCA 240
LNWTDIPVAM EHQPPYIVAV LPRYVEIRTL EPRLLVQSIE LQRPRFITSG GSNIIYVASN 300
HFVWRLIPVP MATQIQQLLQ DKQFELALQL AEMKDDSDSE KQQQIHHIKN LYAFNLFCQK 360
RFDESMQVFA KLGTDPTHVM GLYPDLLPTD YRKQLQYPNP LPTLSGAELE KAHLALIDYL 420
TQKRSQLVKK LNDSDHQSST SPLMEGTPTI KSKKKLLQII DTTLLKCYLH TNVALVAPLL 480
RLENNHCHIE ESEHVLKKAH KYSELIILYE KKGLHEKALQ VLVDQSKKAN SPLKGHERTV 540
QYLQHLGTEN LHLIFSYSVW VLRDFPEDGL KIFTEDLPEV ESLPRDRVLN FLIENFKALA 600
IPYLEHIIHV WEETGSQFHN CLIQLYCEKV QSLMKDYLLS LPTGKSPVPA GEEGGELGEY 660
RQKLLMFLEI SSHYDPGRLI CDFPFDGLLE ERALLLGRMG KHEQALFIYV HVLKDTKMAK 720
EYCHKHYDQN KEGNKDVYLS LLRMYLSPPS IHCLGPIKLE LLEPQANLQA ALQVLELHYS 780
KLDTTKAINL LPANTQINDI RIFLEKVLEE NAQKKRFNQV LKNLLHAEFL RVQEERILHQ 840
QVKCIITEEK VCMVCKKKIG NSAFARYPNG VVVHYFCSKE VNSADT 886 |
Gene Ontology | GO:0030897; C:HOPS complex; IEA:Compara. GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. GO:0005083; F:small GTPase regulator activity; IEA:InterPro. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0016192; P:vesicle-mediated transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |