CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016196
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 135 
Protein Synonyms/Alias
 Peroxisomal membrane protein 52; PMP52 
Gene Name
 TMEM135 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
189ALRFIVGKEEIPTHSubiquitination[1, 2]
228NMIGLVRKFVDSICKubiquitination[2]
364LVETMYFKGIEAGKVubiquitination[1]
422KFAVMNRKVLDVFGTubiquitination[1]
433VFGTGASKHFQDFIPubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in peroxisome organization. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Membrane; Peroxisome; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 458 AA 
Protein Sequence
MAALSKSIPH NCYEIGHTWH PSCRVSFLQI TGGALEESLK IYAPLYLIAA ILRKRKLDYY 60
LHKLLPEILQ SASFLTANGA LYMAFFCILR KILGKFYSWT PGFGAALPAS YVAILIERKS 120
RRGLLTIYMA NLATETLFRM GVARGTITTL RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF 180
SALRFIVGKE EIPTHSFSPE AAYAKVEQKR EQHEEKPGRM NMIGLVRKFV DSICKHGPRH 240
RCCKHYEDNC ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL 300
GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IIAGFLAGIS MMFYKSTTIS MYLASKLVET 360
MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL RPSYWKFLLR LTKGKFAVMN 420
RKVLDVFGTG ASKHFQDFIP RLDPRYTTVT PELPTEFS 458 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005777; C:peroxisome; ISS:UniProtKB.
 GO:0007031; P:peroxisome organization; ISS:UniProtKB. 
Interpro
 IPR026749; Tmem135. 
Pfam
  
SMART
  
PROSITE
  
PRINTS