| Tag | Content |
|---|
| CPLM ID | CPLM-015792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carbohydrate sulfotransferase 15 |
Protein Synonyms/Alias | B-cell RAG-associated gene protein; hBRAG; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; GalNAc4S-6ST |
Gene Name | CHST15 |
Gene Synonyms/Alias | BRAG; GALNAC4S6ST; KIAA0598 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 504 | NLGPLSEKQEALMTK | ubiquitination | [1] | | 511 | KQEALMTKSPASNAR | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. |
Sequence Annotation | NP_BIND 263 267 PAPS (By similarity).
BINDING 392 392 PAPS (By similarity).
BINDING 400 400 PAPS (By similarity).
CARBOHYD 364 364 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 561 AA |
Protein Sequence | MRHCINCCIQ LLPDGAHKQQ VNCQGGPHHG HQACPTCKGE NKILFRVDSK QMNLLAVLEV 60
RTEGNENWGG FLRFKKGKRC SLVFGLIIMT LVMASYILSG AHQELLISSP FHYGGFPSNP 120
SLMDSENPSD TKEHHHQSSV NNISYMKDYP SIKLIINSIT TRIEFTTRQL PDLEDLKKQE 180
LHMFSVIPNK FLPNSKSPCW YEEFSGQNTT DPYLTNSYVL YSKRFRSTFD ALRKAFWGHL 240
AHAHGKHFRL RCLPHFYIIG QPKCGTTDLY DRLRLHPEVK FSAIKEPHWW TRKRFGIVRL 300
RDGLRDRYPV EDYLDLFDLA AHQIHQGLQA SSAKEQSKMN TIIIGEASAS TMWDNNAWTF 360
FYDNSTDGEP PFLTQDFIHA FQPNARLIVM LRDPVERLYS DYLYFASSNK SADDFHEKVT 420
EALQLFENCM LDYSLRACVY NNTLNNAMPV RLQVGLYAVY LLDWLSVFDK QQFLILRLED 480
HASNVKYTMH KVFQFLNLGP LSEKQEALMT KSPASNARRP EDRNLGPMWP ITQKILRDFY 540
RPFNARLAQV LADEAFAWKT T 561 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0050656; F:3'-phosphoadenosine 5'-phosphosulfate binding; IDA:UniProtKB. GO:0050659; F:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; IDA:UniProtKB. GO:0030206; P:chondroitin sulfate biosynthetic process; TAS:Reactome. GO:0019319; P:hexose biosynthetic process; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |