CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial import receptor subunit TOM70 
Protein Synonyms/Alias
 Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit 
Gene Name
 Tomm70a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
125AAKNKGNKYFKAGKYacetylation[1]
187KAVELNPKYVKALFRacetylation[1]
435ACIRLRPKFALAQAQacetylation[1]
472KGFEEVIKKFPRCAEacetylation[1]
531QWKQDLDKGLELISKubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Receptor that accelerates the import of all mitochondrial precursor proteins. 
Sequence Annotation
 REPEAT 116 149 TPR 1.
 REPEAT 155 188 TPR 2.
 REPEAT 296 329 TPR 3.
 REPEAT 331 364 TPR 4.
 REPEAT 369 402 TPR 5.
 REPEAT 403 436 TPR 6.
 REPEAT 444 477 TPR 7.
 REPEAT 478 511 TPR 8.
 REPEAT 513 546 TPR 9.
 REPEAT 547 580 TPR 10.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 88 88 Phosphothreonine (By similarity).
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 187 187 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 610 AA 
Protein Sequence
MAASKPVEAA MAAAAAPASG NGVGSSGGTA APGSGAGTLP RWHVALAIGA PLLLGAGAMY 60
LWSRRRRRRE AGGRGDASGL KRNSERKTPE GRASPALGSG PDGSGDSLEM SSLDRAQAAK 120
NKGNKYFKAG KYEQAIQCYT EAISLCPTEK NADLSTFYQN RAAAFEQLQK WKEVAQDCTK 180
AVELNPKYVK ALFRRAKAHE KLDNKKECLE DVTAVCILEG FQNEQSMLLA DKVLKLLGKE 240
NAKEKYKNRE PLMPSPQFIK SYFSSFTDDI ISQPMLKGEK SDEDKDKEGE ALEVKENSGY 300
LKAKQYMEEE NYDKIISECS KEIDAQGKYM AEALLLRATF YLLIGSANAA KPDLDKVISL 360
KEANVKLRAN ALIKRGTMCM QQQQPMLSTQ DFNMAAEIDP MNSDVYHHRG QLKILLDLVE 420
EAVADFDACI RLRPKFALAQ AQKCFALYRQ AYTANNSSQV QAAMKGFEEV IKKFPRCAEG 480
YALYAQALTD QQQFGKADEM YDKCIDLEPD NATTYVHKGL LQLQWKQDLD KGLELISKAI 540
EIDNKCDFAY ETMGTIEVQR GNMEKAIDMF NKAINLAKSE MEMAHLYSLC DAAHAQTEVA 600
KKYGLKPPTL 610 
Gene Ontology
 GO:0016021; C:integral to membrane; TAS:RGD.
 GO:0005741; C:mitochondrial outer membrane; TAS:RGD.
 GO:0015031; P:protein transport; TAS:RGD. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF13174; TPR_6
 PF13181; TPR_8 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS