UniProt Accession

 KLF1_MOUSE; P46099; O70261 

Genbank Protein ID

 M97200; AF019074; AF033102 

Genbank Nucleotide ID

 AAA37546.1; AAB87861.1; AAC24497.1 

Protein Name

 Krueppel-like factor 1 

Protein Synonyms/Alias

 Erythroid krueppel-like transcription factor; EKLF 

Gene Name

 Klf1 

Gene Synonyms/Alias

 Elkf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	PSLHVSLKSEDPSGE	sumoylation	[1]

Reference

 [1] Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis.
 Siatecka M, Xue L, Bieker JJ.
 Mol Cell Biol. 2007 Dec;27(24):8547-60. [PMID: 17938210] 

Functional Description

 Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. 

Sequence Annotation

 ZN_FING 275 299 C2H2-type 1.
 ZN_FING 305 329 C2H2-type 2.
 ZN_FING 335 357 C2H2-type 3.
 MOD_RES 23 23 Phosphothreonine; by CK2 (Probable).
 MOD_RES 270 270 N6-acetyllysine.
 MOD_RES 284 284 N6-acetyllysine.
 CROSSLNK 56 56 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Activator; Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; ISS:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006338; P:chromatin remodeling; IDA:MGI.
 GO:0035162; P:embryonic hemopoiesis; IMP:MGI.
 GO:0043249; P:erythrocyte maturation; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS