CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012658
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 
Protein Synonyms/Alias
 ETF-QO; ETF-ubiquinone oxidoreductase; Electron-transferring-flavoprotein dehydrogenase; ETF dehydrogenase 
Gene Name
 ETFDH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
153RFGILTEKYRIPVPIubiquitination[1]
223TNDVGIQKDGAPKATubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Accepts electrons from ETF and reduces ubiquinone. 
Sequence Annotation
 DOMAIN 577 606 4Fe-4S ferredoxin-type.
 NP_BIND 71 85 FAD (Potential).
 METAL 561 561 Iron-sulfur (4Fe-4S) (Potential).
 METAL 586 586 Iron-sulfur (4Fe-4S) (Potential).
 METAL 589 589 Iron-sulfur (4Fe-4S) (Potential).
 METAL 592 592 Iron-sulfur (4Fe-4S) (Potential).
 BINDING 305 305 Ubiquinone; via carbonyl oxygen (By
 BINDING 306 306 Ubiquinone; via amide nitrogen (By
 MOD_RES 96 96 N6-acetyllysine (By similarity).
 MOD_RES 153 153 N6-acetyllysine (By similarity).
 MOD_RES 223 223 N6-acetyllysine (By similarity).
 MOD_RES 344 344 N6-acetyllysine (By similarity).  
Keyword
 4Fe-4S; Acetylation; Complete proteome; Electron transport; FAD; Flavoprotein; Glutaricaciduria; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide; Transport; Ubiquinone. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MLVPLAKLSC LAYQCFHALK IKKNYLPLCA TRWSSTSTVP RITTHYTIYP RDKDKRWEGV 60
NMERFAEEAD VVIVGAGPAG LSAAVRLKQL AVAHEKDIRV CLVEKAAQIG AHTLSGACLD 120
PGAFKELFPD WKEKGAPLNT PVTEDRFGIL TEKYRIPVPI LPGLPMNNHG NYIVRLGHLV 180
SWMGEQAEAL GVEVYPGYAA AEVLFHDDGS VKGIATNDVG IQKDGAPKAT FERGLELHAK 240
VTIFAEGCHG HLAKQLYKKF DLRANCEPQT YGIGLKELWV IDEKNWKPGR VDHTVGWPLD 300
RHTYGGSFLY HLNEGEPLVA LGLVVGLDYQ NPYLSPFREF QRWKHHPSIR PTLEGGKRIA 360
YGARALNEGG FQSIPKLTFP GGLLIGCSPG FMNVPKIKGT HTAMKSGILA AESIFNQLTS 420
ENLQSKTIGL HVTEYEDNLK NSWVWKELYS VRNIRPSCHG VLGVYGGMIY TGIFYWILRG 480
MEPWTLKHKG SDFERLKPAK DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLR 540
DDSIPVNRNL SIYDGPEQRF CPAGVYEFVP VEQGDGFRLQ INAQNCVHCK TCDIKDPSQN 600
INWVVPEGGG GPAYNGM 617 
Gene Ontology
 GO:0031305; C:integral to mitochondrial inner membrane; IDA:UniProtKB.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
 GO:0009055; F:electron carrier activity; IDA:UniProtKB.
 GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; IDA:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043783; F:oxidoreductase activity, oxidizing metal ions with flavin as acceptor; ISS:UniProtKB.
 GO:0048039; F:ubiquinone binding; IDA:UniProtKB.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IMP:BHF-UCL.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0006979; P:response to oxidative stress; ISS:UniProtKB. 
Interpro
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR007859; ETFD_OxRdtase.
 IPR000103; Pyridine_nuc-diS_OxRdtase_2. 
Pfam
 PF05187; ETF_QO 
SMART
  
PROSITE
 PS51379; 4FE4S_FER_2 
PRINTS
 PR00469; PNDRDTASEII.