CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005802
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uroporphyrinogen decarboxylase 
Protein Synonyms/Alias
 UPD; URO-D 
Gene Name
 hemE 
Gene Synonyms/Alias
 b3997; JW3961 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
37GRYLPEYKATRAQAGacetylation[1]
111TCKADVDKLPIPDPEacetylation[1]
184ALHALLDKLAKSVTLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity). 
Sequence Annotation
 REGION 27 31 Substrate binding (By similarity).
 BINDING 46 46 Substrate (By similarity).
 BINDING 77 77 Substrate (By similarity).
 BINDING 154 154 Substrate (By similarity).
 BINDING 209 209 Substrate (By similarity).
 BINDING 327 327 Substrate (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Decarboxylase; Lyase; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MTELKNDRYL RALLRQPVDV TPVWMMRQAG RYLPEYKATR AQAGDFMSLC KNAELACEVT 60
LQPLRRYPLD AAILFSDILT VPDAMGLGLY FEAGEGPRFT SPVTCKADVD KLPIPDPEDE 120
LGYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTVIKKM MYADPQALHA 180
LLDKLAKSVT LYLNAQIKAG AQAVMIFDTW GGVLTGRDYQ QFSLYYMHKI VDGLLRENDG 240
RRVPVTLFTK GGGQWLEAMA ETGCDALGLD WTTDIADARR RVGNKVALQG NMDPSMLYAP 300
PARIEEEVAT ILAGFGHGEG HVFNLGHGIH QDVPPEHAGV FVEAVHRLSE QYHR 354 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004853; F:uroporphyrinogen decarboxylase activity; IMP:EcoCyc.
 GO:0019353; P:protoporphyrinogen IX biosynthetic process from glutamate; IMP:EcoCyc.
 GO:0006780; P:uroporphyrinogen III biosynthetic process; IMP:EcoliWiki. 
Interpro
 IPR006361; Uroporphyrinogen_deCO2ase_HemE.
 IPR000257; Uroporphyrinogen_deCOase. 
Pfam
 PF01208; URO-D 
SMART
  
PROSITE
 PS00906; UROD_1
 PS00907; UROD_2 
PRINTS