CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007805
UniProt Accession
Genbank Protein ID
 X81986 
Genbank Nucleotide ID
Protein Name
 26S protease regulatory subunit 8 
Protein Synonyms/Alias
 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; SUG1 homolog; xSUG1 
Gene Name
 psmc5 
Gene Synonyms/Alias
 sug1 
Created Date
 July 27, 2013 
Organism
 Xenopus laevis (African clawed frog) 
NCBI Taxa ID
 8355 
Lysine Modification
Position
Peptide
Type
References
83DKKKVLVKVHPEGKFubiquitination[1]
96KFVVDVDKNIDINDVubiquitination[1]
120NDSYTLHKILPNKVDubiquitination[1]
217SGSELVQKFIGEGARubiquitination[1]
281LDGFEATKNIKVIMAubiquitination[1]
324EARLDILKIHSRKMNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). 
Sequence Annotation
 NP_BIND 185 192 ATP (Potential).  
Keyword
 ATP-binding; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 461 AA 
Protein Sequence
MEQMEMDESR GGTGLRQYYL SKIEDLQLVV NDKSQNLRRL QAQRNELNAK VRLLREELQL 60
LQEQGSYVGE VVRAMDKKKV LVKVHPEGKF VVDVDKNIDI NDVTPNCRVA LRNDSYTLHK 120
ILPNKVDPLV SLMMVEKVPD STYEMIGGLD KQIKEIKEVI ELPVKHPEHF EALGIAQPKG 180
VLLYGPPGTG KTLLARAVAH HTDCTFIRVS GSELVQKFIG EGARMVRELF VMAREHAPSI 240
IFMDEIDSIG SRLEGGSGGD SEVQRTMLEL LNQLDGFEAT KNIKVIMATN RIDILDSALL 300
RPGRIDRKIE FPPPNEEARL DILKIHSRKM NLTRGINLRK IAELMPGASG AEVKGVCTEA 360
GMYALRERRV HVTQEDFEMA VAKVMQKDSE KNMSIKKLWK CFFLVPILCS TVCFQLKPSD 420
VYYMGAWLIK PTRFNRRIIT NSYHLQIFKP TIVLANGECH N 461 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0030163; P:protein catabolic process; IEA:InterPro. 
Interpro
 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS