UniProt Accession

 GSTM2_HUMAN; P28161; B4DRY4; E9PEM9; Q2M318; Q5TZY5; Q8WWE1 

Genbank Protein ID

 M63509; AK299482; BT019947; AC000031; AC000032; BC105038; BC105066 

Genbank Nucleotide ID

 AAA60963.1; BAG61446.1; AAV38750.1; AAI05039.1; AAI05067.1 

Protein Name

 Glutathione S-transferase Mu 2 

Protein Synonyms/Alias

 GST class-mu 2; GSTM2-2 

Gene Name

 GSTM2 

Gene Synonyms/Alias

 GST4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
144	LYSQFLGKQPWFLGD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. 

Sequence Annotation

 DOMAIN 2 88 GST N-terminal.
 DOMAIN 90 208 GST C-terminal.
 REGION 7 8 Glutathione binding.
 REGION 46 50 Glutathione binding.
 REGION 59 60 Glutathione binding.
 REGION 72 73 Glutathione binding.
 BINDING 116 116 Substrate (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0016529; C:sarcoplasmic reticulum; IDA:BHF-UCL.
 GO:0043295; F:glutathione binding; IDA:BHF-UCL.
 GO:0004364; F:glutathione transferase activity; IDA:UniProtKB.
 GO:0070458; P:cellular detoxification of nitrogen compound; IDA:BHF-UCL.
 GO:0071313; P:cellular response to caffeine; IDA:BHF-UCL.
 GO:0006749; P:glutathione metabolic process; IDA:UniProtKB.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
 GO:0018916; P:nitrobenzene metabolic process; IDA:BHF-UCL.
 GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IC:BHF-UCL.
 GO:0014809; P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; IC:BHF-UCL.
 GO:0055119; P:relaxation of cardiac muscle; TAS:BHF-UCL.
 GO:0042178; P:xenobiotic catabolic process; IDA:UniProtKB. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003081; GST_mu.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01267; GSTRNSFRASEM.