CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004393
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Desmoplakin 
Protein Synonyms/Alias
 DP; 250/210 kDa paraneoplastic pemphigus antigen 
Gene Name
 DSP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94LIVQPELKYGDGIQLubiquitination[1]
245IKADLREKSAIYQLEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. 
Sequence Annotation
 REPEAT 178 271 Spectrin 1.
 REPEAT 272 375 Spectrin 2.
 REPEAT 376 446 Spectrin 3a.
 DOMAIN 447 515 SH3.
 REPEAT 516 545 Spectrin 3b.
 REPEAT 546 627 Spectrin 4.
 REPEAT 654 769 Spectrin 5.
 REPEAT 770 883 Spectrin 6.
 REPEAT 2009 2045 Plectin 1.
 REPEAT 2046 2083 Plectin 2.
 REPEAT 2084 2121 Plectin 3.
 REPEAT 2122 2159 Plectin 4.
 REPEAT 2163 2197 Plectin 5.
 REPEAT 2198 2233 Plectin 6.
 REPEAT 2251 2288 Plectin 7.
 REPEAT 2289 2326 Plectin 8.
 REPEAT 2327 2364 Plectin 9.
 REPEAT 2365 2402 Plectin 10.
 REPEAT 2406 2440 Plectin 11.
 REPEAT 2456 2493 Plectin 12.
 REPEAT 2507 2544 Plectin 13.
 REPEAT 2610 2647 Plectin 14.
 REPEAT 2648 2685 Plectin 15.
 REPEAT 2724 2761 Plectin 16.
 REPEAT 2762 2799 Plectin 17.
 REGION 1 1056 Globular 1.
 REGION 1 584 Interacts with plakophilin 1 and junction
 REGION 1057 1945 Central fibrous rod domain.
 REGION 1946 2871 Globular 2.
 REGION 1960 2208 4.5 X 38 AA tandem repeats (Domain A).
 REGION 2244 2446 4.5 X 38 AA tandem repeats (Domain B).
 REGION 2609 2822 4.5 X 38 AA tandem repeats (Domain C).
 REGION 2824 2847 6 X 4 AA tandem repeats of G-S-R-[SR].
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 165 165 Phosphoserine.
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 176 176 Phosphoserine.
 MOD_RES 2024 2024 Phosphoserine.
 MOD_RES 2207 2207 Phosphoserine.
 MOD_RES 2209 2209 Phosphoserine.
 MOD_RES 2815 2815 Phosphoserine.
 MOD_RES 2820 2820 Phosphoserine.
 MOD_RES 2821 2821 Phosphoserine.
 MOD_RES 2825 2825 Phosphoserine.
 MOD_RES 2849 2849 Phosphoserine.
 MOD_RES 2853 2853 Phosphothreonine.
 MOD_RES 2868 2868 Phosphoserine.
 LIPID 2480 2480 Omega-hydroxyceramide glutamate ester  
Keyword
 3D-structure; Alternative splicing; Cardiomyopathy; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Epidermolysis bullosa; Lipoprotein; Palmoplantar keratoderma; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2871 AA 
Protein Sequence
MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD QNSDGYCQTG 60
TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ LTRSRELDEC FAQANDQMEI 120
LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR ALYKAISVPR VRRASSKGGG GYTCQSGSGW 180
DEFTKHVTSE CLGWMRQQRA EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA 240
DLREKSAIYQ LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD 300
KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY MDTLQTQWSW 360
ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR KKYPCDKNMP LQHLLEQIKE 420
LEKEREKILE YKRQVQNLVN KSKKIVQLKP RNPDYRSNKP IILRALCDYK QDQKIVHKGD 480
ECILKDNNER SKWYVTGPGG VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL 540
YINMKSLVSW HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF 600
GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN HNKVIETNRE 660
NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH HITVKINELK SVQNDSQAIA 720
EVLNQLKDML ANFRGSEKYC YLQNEVFGLF QKLENINGVT DGYLNSLCTV RALLQAILQT 780
EDMLKVYEAR LTEEETVCLD LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS 840
QTSQQYPLYD LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK 900
WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI AELCANSIKD 960
YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH ARYIELLTRS GDYYRFLSEM 1020
LKSLEDLKLK NTKIEVLEEE LRLARDANSE NCNKNKFLDQ NLQKYQAECS QFKAKLASLE 1080
ELKRQAELDG KSAKQNLDKC YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD 1140
QLQKARQCEK ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKASNRIQ 1200
ESKNQCTQVV QERESLLVKI KVLEQDKARL QRLEDELNRA KSTLEAETRV KQRLECEKQQ 1260
IQNDLNQWKT QYSRKEEAIR KIESEREKSE REKNSLRSEI ERLQAEIKRI EERCRRKLED 1320
STRETQSQLE TERSRYQREI DKLRQRPYGS HRETQTECEW TVDTSKLVFD GLRKKVTAMQ 1380
LYECQLIDKT TLDKLLKGKK SVEEVASEIQ PFLRGAGSIA GASASPKEKY SLVEAKRKKL 1440
ISPESTVMLL EAQAATGGII DPHRNEKLTV DSAIARDLID FDDRQQIYAA EKAITGFDDP 1500
FSGKTVSVSE AIKKNLIDRE TGMRLLEAQI ASGGVVDPVN SVFLPKDVAL ARGLIDRDLY 1560
RSLNDPRDSQ KNFVDPVTKK KVSYVQLKER CRIEPHTGLL LLSVQKRSMS FQGIRQPVTV 1620
TELVDSGILR PSTVNELESG QISYDEVGER IKDFLQGSSC IAGIYNETTK QKLGIYEAMK 1680
IGLVRPGTAL ELLEAQAATG FIVDPVSNLR LPVEEAYKRG LVGIEFKEKL LSAERAVTGY 1740
NDPETGNIIS LFQAMNKELI EKGHGIRLLE AQIATGGIID PKESHRLPVD IAYKRGYFNE 1800
ELSEILSDPS DDTKGFFDPN TEENLTYLQL KERCIKDEET GLCLLPLKEK KKQVQTSQKN 1860
TLRKRRVVIV DPETNKEMSV QEAYKKGLID YETFKELCEQ ECEWEEITIT GSDGSTRVVL 1920
VDRKTGSQYD IQDAIDKGLV DRKFFDQYRS GSLSLTQFAD MISLKNGVGT SSSMGSGVSD 1980
DVFSSSRHES VSKISTISSV RNLTIRSSSF SDTLEESSPI AAIFDTENLE KISITEGIER 2040
GIVDSITGQR LLEAQACTGG IIHPTTGQKL SLQDAVSQGV IDQDMATRLK PAQKAFIGFE 2100
GVKGKKKMSA AEAVKEKWLP YEAGQRFLEF QYLTGGLVDP EVHGRISTEE AIRKGFIDGR 2160
AAQRLQDTSS YAKILTCPKT KLKISYKDAI NRSMVEDITG LRLLEAASVS SKGLPSPYNM 2220
SSAPGSRSGS RSGSRSGSRS GSRSGSRRGS FDATGNSSYS YSYSFSSSSI GH 2272 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0001533; C:cornified envelope; IDA:UniProtKB.
 GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
 GO:0014704; C:intercalated disc; IDA:BHF-UCL.
 GO:0005882; C:intermediate filament; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0030674; F:protein binding, bridging; IDA:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0034332; P:adherens junction organization; IEA:Compara.
 GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IMP:BHF-UCL.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0002934; P:desmosome organization; ISS:BHF-UCL.
 GO:0045109; P:intermediate filament organization; ISS:BHF-UCL.
 GO:0030216; P:keratinocyte differentiation; IDA:UniProtKB.
 GO:0018149; P:peptide cross-linking; IDA:UniProtKB.
 GO:0071896; P:protein localization to adherens junction; ISS:BHF-UCL.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0003223; P:ventricular compact myocardium morphogenesis; ISS:BHF-UCL. 
Interpro
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00681; Plectin 
SMART
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS50002; SH3 
PRINTS