CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044352
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Fascin 
Protein Synonyms/Alias
  
Gene Name
 FSCN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53GRYLAADKDGNVTCEacetylation[1]
53GRYLAADKDGNVTCEubiquitination[2]
220SGPSGTLKAGKATKVubiquitination[3]
229GKATKVGKDELFALEubiquitination[2]
450KVGGRYLKGDHAGVLacetylation[4]
458GDHAGVLKASAETVDubiquitination[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 472 AA 
Protein Sequence
MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKNHLGRYLA ADKDGNVTCE 60
REVPGPDCRF LIVAHDDGRW SLQSEAHRRY FGGTEDRLSC FAQTVSPAEK WSVHIAMHPQ 120
VNIYSVTRKR YAHLSARPAD EIAVDRDVPW GVDSLITLAF QDQRYSVQTA DHRFLRHDGR 180
LVARPEPATG YTLEFRSGKV AFRDCEGRYL APSGPSGTLK AGKATKVGKD ELFALEQSCA 240
QVVLQAANER NVSTRQGMDL SANQDEETDQ ETFQLEIDRD TKKCAFRTHT GKYWTLTATG 300
GVQSTASSKN ASCYFDIEWR DRRITLRASN GKFVTSKKNG QLAASVETAG DSELFLMKLI 360
NRPIIVFRGE HGFIGCRKVT GTLDANRSSY DVFQLEFNDG AYNIKDSTGK YWTVGSDSAV 420
TSSGDTPVDF FFEFCDYNKV AIKVGGRYLK GDHAGVLKAS AETVDPASLW EY 472 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 
Interpro
 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain.
 IPR024703; Fascin_metazoans. 
Pfam
 PF06268; Fascin 
SMART
  
PROSITE
  
PRINTS