UniProt Accession

 H0YCB3_HUMAN; H0YCB3 

Genbank Protein ID

 AC022392; AL607035 

Genbank Nucleotide ID

  

Protein Name

 Activating signal cointegrator 1 complex subunit 1 

Protein Synonyms/Alias

  

Gene Name

 ASCC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
251	FDGRNILKSFALLPR	ubiquitination	[1, 2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 

Interpro

 IPR009210; Euk_LigT.
 IPR004088; KH_dom_type_1.
 IPR019510; Kinase-A_anchor_nucl_local_sig.
 IPR009097; RNA_ligase/cNuc_Pdiesterase. 

Pfam

 PF10469; AKAP7_NLS
 PF13014; KH_3 

SMART

  

PROSITE

 PS50084; KH_TYPE_1 

PRINTS