CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042689
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glutathione reductase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 GSR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53AAVVESHKLGGTCVNacetylation[1]
53AAVVESHKLGGTCVNubiquitination[2]
67NVGCVPKKVMWNTAVubiquitination[2]
254SQVKEVKKTLSGLEVubiquitination[3]
294IGRVPNTKDLSLNKLubiquitination[2, 4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 301 AA 
Protein Sequence
XCRQEPQPQG PPPAAGAVAS YDYLVIGGGS GGLASARRAA ELGARAAVVE SHKLGGTCVN 60
VGCVPKKVMW NTAVHSEFMH DHADYGFPSC EGKFNWRVIK EKRDAYVSRL NAIYQNNLTK 120
SHIEIIRGHA AFTSDPKPTI EVSGKKYTAP HILIATGGMP STPHESQIPG ASLGITSDGF 180
FQLEELPGVI VGAGYIAVEM AGILSALGSK TSLMIRHDKV LRSFDSMIST NCTEELENAG 240
VEVLKFSQVK EVKKTLSGLE VSMVTAVPGR LPVMTMIPDV DCLLWAIGRV PNTKDLSLNK 300
L 301 
Gene Ontology
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0016668; F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; IEA:InterPro. 
Interpro
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.