UniProt Accession

 GNA1_MOUSE; Q9JK38 

Genbank Protein ID

 AJ001006; AK018499; AK002466; AK007647; AK007722; AK007764; AK008566; AK011098; BC031116 

Genbank Nucleotide ID

 CAA04463.1; BAB31241.1; BAB22120.1; BAB25161.1; BAB25212.1; BAB25240.1; BAB25749.1; BAB27395.1; AAH31116.1 

Protein Name

 Glucosamine 6-phosphate N-acetyltransferase 

Protein Synonyms/Alias

 Phosphoglucosamine acetylase; Phosphoglucosamine transacetylase; Protein EMeg32 

Gene Name

 Gnpnat1 

Gene Synonyms/Alias

 Gna1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
2	******MKPDETPMF	acetylation	[1]
55	DLNKGFFKVLGQLTE	ubiquitination	[2]
115	KFIHSCAKRGRVEDV	ubiquitination	[2]
166	PQNVGFYKKFDYTVS	acetylation	[3]
167	QNVGFYKKFDYTVSE	acetylation	[3]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

 DOMAIN 39 184 N-acetyltransferase.
 REGION 108 111 Substrate binding (By similarity).
 REGION 120 122 Substrate binding (By similarity).
 REGION 130 135 Acetyl-CoA binding (By similarity).
 REGION 151 152 Substrate binding (By similarity).
 REGION 165 167 Acetyl-CoA binding (By similarity).
 BINDING 61 61 Substrate (By similarity).
 BINDING 175 175 Substrate (By similarity).
 BINDING 181 181 Substrate (By similarity).  

Keyword

 Acyltransferase; Complete proteome; Endosome; Golgi apparatus; Membrane; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:MGI.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IDA:MGI.
 GO:0004343; F:glucosamine 6-phosphate N-acetyltransferase activity; IDA:MGI.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0006041; P:glucosamine metabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0006044; P:N-acetylglucosamine metabolic process; IEA:Compara.
 GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; TAS:MGI. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS