CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004705
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Syndecan-1 
Protein Synonyms/Alias
 SYND1; CD138 
Gene Name
 Sdc1 
Gene Synonyms/Alias
 Synd-1; Synd1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
282MLYRMKKKDEGSYSLubiquitination[1]
302ANGGAYQKPTKQEEFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. 
Sequence Annotation
 CARBOHYD 37 37 O-linked (Xyl...) (chondroitin sulfate)
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
 CARBOHYD 45 45 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 47 47 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 207 207 O-linked (Xyl...) (chondroitin sulfate).
 CARBOHYD 217 217 O-linked (Xyl...) (chondroitin sulfate).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Heparan sulfate; Membrane; Proteoglycan; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 311 AA 
Protein Sequence
MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG ALPDTLSRQT 60
PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE GEPVLHVEAE PGFTARDKEK 120
EVTTRPRETV QLPITQRAST VRVTTAQAAV TSHPHGGMQP GLHETSAPTA PGQPDHQPPR 180
VEGGGTSVIK EVVEDGTANQ LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA 240
TGASQSLLDR KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 300
QKPTKQEEFY A 311 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:MGI.
 GO:0048627; P:myoblast development; IDA:UniProtKB.
 GO:0042476; P:odontogenesis; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0060009; P:Sertoli cell development; IEA:Compara.
 GO:0055002; P:striated muscle cell development; IEA:Compara.
 GO:0001657; P:ureteric bud development; IEA:Compara.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR003585; Neurexin-like.
 IPR001050; Syndecan. 
Pfam
 PF01034; Syndecan 
SMART
 SM00294; 4.1m 
PROSITE
 PS00964; SYNDECAN 
PRINTS