| Tag | Content |
|---|
| CPLM ID | CPLM-006149 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 26S proteasome regulatory subunit RPN12 |
Protein Synonyms/Alias | Nuclear integrity protein 1 |
Gene Name | RPN12 |
Gene Synonyms/Alias | NIN1; YFR052W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 147 | SLLSYPIKLDRWLME | acetylation | [1] | | 219 | NNEKETEKFALERNW | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase. |
Sequence Annotation | |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Proteasome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 274 AA |
Protein Sequence | MPSLAELTKS LSIAFENGDY AACEKLLPPI KIELIKNNLL IPDLSIQNDI YLNDLMITKR 60
ILEVGALASI QTFNFDSFEN YFNQLKPYYF SNNHKLSESD KKSKLISLYL LNLLSQNNTT 120
KFHSELQYLD KHIKNLEDDS LLSYPIKLDR WLMEGSYQKA WDLLQSGSQN ISEFDSFTDI 180
LKSAIRDEIA KNTELSYDFL PLSNIKALLF FNNEKETEKF ALERNWPIVN SKVYFNNQSK 240
EKADYEDEMM HEEDQKTNII EKAMDYAISI ENIV 274 |
Gene Ontology | GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:SGD. GO:0034515; C:proteasome storage granule; IDA:SGD. GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:SGD. |
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PROSITE | |
PRINTS | |