CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008556
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable alanine aminotransferase, mitochondrial 
Protein Synonyms/Alias
 Glutamate pyruvate transaminase; GPT; Glutamic--alanine transaminase; Glutamic--pyruvic transaminase 
Gene Name
 ALT1 
Gene Synonyms/Alias
 YLR089C; L9449.15 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
124NENVLKAKYAVRGAIubiquitination[1]
144ELKAQLEKDPQSLPFacetylation[2]
483ERNSIHEKLITRAMTacetylation[2]
577APGLEWIKKWESFHKacetylation[2]
Reference
 [1] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
  
Sequence Annotation
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 412 412 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Aminotransferase; Complete proteome; Mitochondrion; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 592 AA 
Protein Sequence
MLSLSAKNHF TVSNSITHVI KSYHIRTLTS SAEKMPHITT PFSTSASSTK LKAFRKVRPV 60
LQRHSSSWIV AQNHRRSLSG QSSLNDLRHL NRFPHHTLKT SNNEFYPAEQ LTLEDVNENV 120
LKAKYAVRGA IPMRAEELKA QLEKDPQSLP FDRIINANIG NPQQLQQKPL TYYRQVLSLL 180
QYPELLNQNE QQLVDSKLFK LDAIKRAKSL MEDIGGSVGA YSSSQGVEGI RKSVAEFITK 240
RDEGEISYPE DIFLTAGASA AVNYLLSIFC RGPETGVLIP IPQYPLYTAT LALNNSQALP 300
YYLDENSGWS TNPEEIETVV KEAIQNEIKP TVLVVINPGN PTGAVLSPES IAQIFEVAAK 360
YGTVVIADEV YQENIFPGTK FHSMKKILRH LQREHPGKFD NVQLASLHST SKGVSGECGQ 420
RGGYMELTGF SHEMRQVILK LASISLCPVV TGQALVDLMV RPPVEGEESF ESDQAERNSI 480
HEKLITRAMT LYETFNSLEG IECQKPQGAM YLFPKIDLPF KAVQEARHLE LTPDEFYCKK 540
LLESTGICTV PGSGFGQEPG TYHLRTTFLA PGLEWIKKWE SFHKEFFDQY RD 592 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IMP:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006523; P:alanine biosynthetic process; IMP:SGD.
 GO:0006524; P:alanine catabolic process; IMP:SGD.
 GO:0001300; P:chronological cell aging; IMP:SGD.
 GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2 
SMART
  
PROSITE
  
PRINTS