UniProt Accession

 MSS51_YEAST; P32335; D6VYK4 

Genbank Protein ID

 J01487; S43721; U14913; BK006945 

Genbank Nucleotide ID

 AAA66926.1; AAB23218.1; AAB67438.1; DAA09520.1 

Protein Name

 Protein MSS51, mitochondrial 

Protein Synonyms/Alias

 Mitochondrial splicing suppressor protein 51 

Gene Name

 MSS51 

Gene Synonyms/Alias

 YLR203C; L8167.17 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
216	PITLEGLKSLAALRY	ubiquitination	[1]
382	TDDINLVKSKYGKEM	acetylation	[2]
387	LVKSKYGKEMDVLME	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Has a dual role in the assembly of cytochrome oxidase subunit 1 (COX1). It has a regulative function on COX1 synthesis, acting as a translational activator specific for the COX1 mRNA, and it also binds to newly synthesized COX1 protein. Together with COX14, may act as a chaperone that binds efficiently unassembled COX1 and prevents it from unproductive aggregation. When bound to COX1, MSS51 is unable to interact with the COX1 mRNA and translation is halted. This may be a feedback control that ensures that COX1 is only produced as long as potentially harmful assembly intermediates are not accumulating. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing; mRNA splicing; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 436 AA 

Protein Sequence

Gene Ontology

 GO:0031314; C:extrinsic to mitochondrial inner membrane; IDA:SGD.
 GO:0045182; F:translation regulator activity; IMP:SGD.
 GO:0097034; P:mitochondrial respiratory chain complex IV biogenesis; IMP:SGD.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0070131; P:positive regulation of mitochondrial translation; IMP:SGD.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR013272; YL1_C. 

Pfam

  

SMART

 SM00993; YL1_C 

PROSITE

  

PRINTS