CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039951
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Eukaryotic translation initiation factor 4 gamma 3 
Protein Synonyms/Alias
  
Gene Name
 EIF4G3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
498RRSIGNIKFIGELFKubiquitination[1, 2]
673EKIQLVPKAQLGSWGubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1189 AA 
Protein Sequence
MKLECIPAPI TPSTVPSFPP TPPTPPASPP HTPVIVPAAA TTVSSPSAAI TVQRVLEEDE 60
SIRTCLSEDA KEIQNKIEVE ADGQTEEILD SQNLNSRRSP VPAQIAITVP KTWKKPKDRT 120
RTTEEMLEAE LELKAEEELS IDKVLESEQD KMSQGFHPER DPSDLKKVKA VEENGEEAEP 180
VRNGAESVSE GEGIDANSGS TDSSGDGVTF PFKPESWKPT DTEGKKQYDR EFLLDFQFMP 240
ACIQKPEGLP PISDVVLDKI NQPKLPMRTL DPRILPRGPD FTPAFADFGR QTPGGRGVPL 300
LNVGSRRSQP GQRREPRKII TVSVKEDVHL KKAENAWKPS QKRDSQADDP ENIKTQELFR 360
KVRSILNKLT PQMFNQLMKQ VSGLTVDTEE RLKGVIDLVF EKAIDEPSFS VAYANMCRCL 420
VTLKVPMADK PGNTVNFRKL LLNRCQKEFE KDKADDDVFE KKQKELEAAS APEERTRLHD 480
ELEEAKDKAR RRSIGNIKFI GELFKLKMLT EAIMHDCVVK LLKNHDEESL ECLCRLLTTI 540
GKDLDFEKAK PRMDQYFNQM EKIVKERKTS SRIRFMLQDV IDLRLCNWVS RRADQGPKTI 600
EQIHKEAKIE EQEEQRKVQQ LMTKEKRRPG VQRVDEGGWN TVQGAKNSRV LDPSKFLKIT 660
KPTIDEKIQL VPKAQLGSWG KGSSGGAKAS ETDALRSSAS SLNRFSALQP PAPSGSTPST 720
PVEFDSRRTL TSRGSMGREK NDKPLPSATA RPNTFMRGGS SKDLLDNQSQ EEQRREMLET 780
VKQLTGGVDV ERNSTEAERN KTRESAKPEI SAMSAHDKAA LSEEELERKS KSIIDEFLHI 840
NDFKEAMQCV EELNAQGLLH VFVRVGVEST LERSQITRDH MGQLLYQLVQ SEKLSKQDFF 900
KGFSETLELA DDMAIDIPHI WLYLAELVTP MLKEGGISMR ELTIEFSKPL LPVGRAGVLL 960
SEILHLLCKQ MSHKKVGALW READLSWKDF LPEGEDVHNF LLEQKLDFIE SDSPCSSEAL 1020
SKKELSAEEL YKRLEKLIIE DKANDEQIFD WVEANLDEIQ MSSPTFLRAL MTAVCKAAII 1080
ADSSTFRVDT AVIKQRVPIL LKYLDSDTEK ELQALYALQA SIVKLDQPAN LLRMFFDCLY 1140
DEEVISEDAF YKWESSKDPA EQNGKGVALK SVTAFFTWLR EAEEESEDN 1189 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara.
 GO:0016070; P:RNA metabolic process; IEA:InterPro.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3.
 IPR003307; W2_domain. 
Pfam
 PF02847; MA3
 PF02854; MIF4G
 PF02020; W2 
SMART
 SM00515; eIF5C
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI
 PS51363; W2 
PRINTS