UniProt Accession

 KAT1_HUMAN; Q16773; Q5T275; Q8N191 

Genbank Protein ID

 X82224; AL441992; AL441992; BC021262; BC033685 

Genbank Nucleotide ID

 CAA57702.1; CAI15414.1; CAI15415.1; AAH21262.1; AAH33685.1 

Protein Name

 Kynurenine--oxoglutarate transaminase 1 

Protein Synonyms/Alias

 Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase I 

Gene Name

 CCBL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKQLQARRL	ubiquitination	[1]
247	LTIGSAGKTFSATGW	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. 

Sequence Annotation

 BINDING 36 36 Substrate; via amide nitrogen.
 BINDING 185 185 Substrate.
 BINDING 398 398 Substrate.
 MOD_RES 247 247 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Alternative splicing; Aminotransferase; Complete proteome; Cytoplasm; Lyase; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 422 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IEA:EC.
 GO:0047316; F:glutamine-phenylpyruvate transaminase activity; IEA:EC.
 GO:0016212; F:kynurenine-oxoglutarate transaminase activity; IDA:UniProtKB.
 GO:0047945; F:L-glutamine:pyruvate aminotransferase activity; EXP:Reactome.
 GO:0036141; F:L-phenylalanine-oxaloacetate transaminase activity; TAS:Reactome.
 GO:0047312; F:L-phenylalanine:pyruvate aminotransferase activity; EXP:Reactome.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008652; P:cellular amino acid biosynthetic process; TAS:Reactome.
 GO:0097053; P:L-kynurenine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006559; P:L-phenylalanine catabolic process; TAS:Reactome.
 GO:0006569; P:tryptophan catabolic process; TAS:Reactome. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

  

PRINTS