UniProt Accession

 TYB4Y_HUMAN; O14604; Q0VDA2 

Genbank Protein ID

 AF000989; AC006371; BC022482; BC119763; BC119764 

Genbank Nucleotide ID

 AAC51836.1; AAD54509.1; AAI19764.1; AAI19765.1 

Protein Name

 Thymosin beta-4, Y-chromosomal 

Protein Synonyms/Alias

  

Gene Name

 TMSB4Y 

Gene Synonyms/Alias

 TB4Y 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MSDKPGMAEIE	acetylation	[1, 2]
12	PGMAEIEKFDKSKLK	acetylation	[1, 2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). 

Sequence Annotation

  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 44 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0042989; P:sequestering of actin monomers; TAS:ProtInc. 

Interpro

 IPR001152; Thymosin_b4.
 IPR016323; Thymosin_b4_chordata. 

Pfam

 PF01290; Thymosin 

SMART

 SM00152; THY 

PROSITE

 PS00500; THYMOSIN_B4 

PRINTS