Tag | Content |
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CPLM ID | CPLM-003668 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SAGA-associated factor 29 homolog |
Protein Synonyms/Alias | rSGF29; Coiled-coil domain-containing protein 101 |
Gene Name | Ccdc101 |
Gene Synonyms/Alias | Sgf29 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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288 | QRYVVACKEPKKK** | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation (By similarity). |
Sequence Annotation | DOMAIN 152 293 SGF29 C-terminal. REGION 194 196 Histone H3K4me3 N-terminus binding (By REGION 240 243 Histone H3K4me3 N-terminus binding (By REGION 264 266 Histone H3K4me3 binding (By similarity). BINDING 238 238 Histone H3K4me3 (By similarity). BINDING 245 245 Histone H3K4me3 (By similarity). MOD_RES 288 288 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 293 AA |
Protein Sequence | MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR 60 GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM 120 TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVAKPGD KVAARVKAVE GDEQWILAEV 180 VSYSHATNKY EVDDIDEEGK ERHTLSRRRI IPLPQWKANP ETDPEALFQK EQLVLALYPQ 240 TTCFYRALIH TPPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK 293 |
Gene Ontology | GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; ISS:UniProtKB. GO:0070461; C:SAGA-type complex; ISS:UniProtKB. GO:0035064; F:methylated histone residue binding; ISS:UniProtKB. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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