UniProt Accession

 RN138_HUMAN; Q8WVD3; B2RE17; Q9H8K2; Q9UF87; Q9UKI6 

Genbank Protein ID

 AF162680; AK023579; AK315761; BT006878; CR457150; CH471088; BC018107; AL133557 

Genbank Nucleotide ID

 AAD46623.2; BAB14614.1; BAG38114.1; AAP35524.1; CAG33431.1; EAX01280.1; AAH18107.1; CAB63712.1 

Protein Name

 E3 ubiquitin-protein ligase RNF138 

Protein Synonyms/Alias

 Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; hNARF; RING finger protein 138 

Gene Name

 RNF138 

Gene Synonyms/Alias

 NARF; HSD-4; HSD4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	PVCQEVLKTPVRTTA	ubiquitination	[1]
41	CQHVFCRKCFLTAMR	acetylation	[2]
41	CQHVFCRKCFLTAMR	ubiquitination	[1]
94	RCCAKQIKFYRMRHH	ubiquitination	[1]
107	HHYKSCKKYQDEYGV	ubiquitination	[1]
158	SSGHPTFKCPLCQES	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 

Sequence Annotation

 ZN_FING 18 58 RING-type.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Ligase; Metal-binding; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Wnt signaling pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR015880; Znf_C2H2-like.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

  

SMART

 SM00184; RING
 SM00355; ZnF_C2H2 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS