CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000115
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein CYR61 
Protein Synonyms/Alias
 CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1 
Gene Name
 CYR61 
Gene Synonyms/Alias
 CCN1; GIG1; IGFBP10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74TQPCDHTKGLECNFGubiquitination[1]
88GASSTALKGICRAQSubiquitination[1]
228YNPLQGQKCIVQTTSubiquitination[1]
241TSWSQCSKTCGTGISubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. 
Sequence Annotation
 DOMAIN 25 94 IGFBP N-terminal.
 DOMAIN 98 164 VWFC.
 DOMAIN 228 273 TSP type-1.
 DOMAIN 286 360 CTCK.
 REGION 279 315 Heparin-binding (By similarity).
 DISULFID 286 323 By similarity.
 DISULFID 303 337 By similarity.
 DISULFID 314 353 By similarity.
 DISULFID 317 355 By similarity.
 DISULFID 322 359 By similarity.  
Keyword
 Cell adhesion; Chemotaxis; Complete proteome; Disulfide bond; Growth factor binding; Heparin-binding; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 381 AA 
Protein Sequence
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 60
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 120
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG 180
KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS 240
KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY 300
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP 360
HANEAAFPFY RLFNDIHKFR D 381 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0050840; F:extracellular matrix binding; IEA:Compara.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0003278; P:apoptotic process involved in heart morphogenesis; IEA:Compara.
 GO:0060413; P:atrial septum morphogenesis; IEA:Compara.
 GO:0003181; P:atrioventricular valve morphogenesis; IEA:Compara.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
 GO:0060591; P:chondroblast differentiation; IEA:Compara.
 GO:0060710; P:chorio-allantoic fusion; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0002041; P:intussusceptive angiogenesis; IEA:Compara.
 GO:0060716; P:labyrinthine layer blood vessel development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0030513; P:positive regulation of BMP signaling pathway; IGI:BHF-UCL.
 GO:0061036; P:positive regulation of cartilage development; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara.
 GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Compara.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IDA:BHF-UCL.
 GO:0033690; P:positive regulation of osteoblast proliferation; IDA:BHF-UCL.
 GO:0010518; P:positive regulation of phospholipase activity; IEA:Compara.
 GO:0045860; P:positive regulation of protein kinase activity; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0072593; P:reactive oxygen species metabolic process; IEA:Compara.
 GO:0001558; P:regulation of cell growth; IEA:InterPro.
 GO:0070372; P:regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL.
 GO:0003281; P:ventricular septum development; IEA:Compara.
 GO:0044319; P:wound healing, spreading of cells; IDA:BHF-UCL. 
Interpro
 IPR006208; Cys_knot.
 IPR006207; Cys_knot_C.
 IPR000867; IGFBP-like.
 IPR012395; IGFBP_CNN.
 IPR017891; Insulin_GF-bd_Cys-rich_CS.
 IPR000884; Thrombospondin_1_rpt.
 IPR001007; VWF_C. 
Pfam
 PF00007; Cys_knot
 PF00219; IGFBP
 PF00090; TSP_1
 PF00093; VWC 
SMART
 SM00041; CT
 SM00121; IB
 SM00209; TSP1
 SM00214; VWC 
PROSITE
 PS01185; CTCK_1
 PS01225; CTCK_2
 PS00222; IGFBP_N_1
 PS51323; IGFBP_N_2
 PS50092; TSP1
 PS01208; VWFC_1
 PS50184; VWFC_2 
PRINTS