| Tag | Content |
|---|
| CPLM ID | CPLM-006283 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Putative acyl-CoA dehydrogenase AidB |
Protein Synonyms/Alias | |
Gene Name | aidB |
Gene Synonyms/Alias | b4187; JW5867 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 293 | EGIRLILKMGGMTRF | acetylation | [1] | | 369 | WDRRADAKEALWARL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro. |
Sequence Annotation | NP_BIND 182 191 FAD.
NP_BIND 216 218 FAD.
NP_BIND 423 433 FAD.
REGION 445 541 dsDNA-binding.
BINDING 185 185 FAD.
BINDING 191 191 FAD.
BINDING 218 218 FAD.
BINDING 429 429 FAD. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; FAD; Flavoprotein; Oxidoreductase; Reference proteome; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 541 AA |
Protein Sequence | MHWQTHTVFN QPIPLNNSNL YLSDGALCEA VTREGAGWDS DFLASIGQQL GTAESLELGR 60
LANVNPPELL RYDAQGRRLD DVRFHPAWHL LMQALCTNRV HNLAWEEDAR SGAFVARAAR 120
FMLHAQVEAG SLCPITMTFA ATPLLLQMLP APFQDWTTPL LSDRYDSHLL PGGQKRGLLI 180
GMGMTEKQGG SDVMSNTTRA ERLEDGSYRL VGHKWFFSVP QSDAHLVLAQ TAGGLSCFFV 240
PRFLPDGQRN AIRLERLKDK LGNRSNASCE VEFQDAIGWL LGLEGEGIRL ILKMGGMTRF 300
DCALGSHAMM RRAFSLAIYH AHQRHVFGNP LIQQPLMRHV LSRMALQLEG QTALLFRLAR 360
AWDRRADAKE ALWARLFTPA AKFVICKRGM PFVAEAMEVL GGIGYCEESE LPRLYREMPV 420
NSIWEGSGNI MCLDVLRVLN KQAGVYDLLS EAFVEVKGQD RYFDRAVRRL QQQLRKPAEE 480
LGREITHQLF LLGCGAQMLK YASPPMAQAW CQVMLDTRGG VRLSEQIQND LLLRATGGVC 540
V 541 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0008470; F:isovaleryl-CoA dehydrogenase activity; IDA:EcoCyc. GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc. GO:0006950; P:response to stress; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |