CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acid-sensing ion channel 1 
Protein Synonyms/Alias
  
Gene Name
 ASIC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
61QVFTRYGKCYTFNSGubiquitination[1]
242CNLTRYGKELSMVKIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
XIRDMLLSCH FRGEVCSAED FKVKPMQVAK ELRRCTLPGT VFQGTQRARK GEKQVFTRYG 60
KCYTFNSGRD GRPRLKTMKG GTGNGLEIML DIQQDEYLPV WGETDETSFE AGIKVQIHSQ 120
DEPPFIDQLG FGVAPGFQTF VACQEQRLIY LPPPWGTCKA VTMDSDLDFF DSYSITACRI 180
DCETRYLVEN CNCRMVHMPG DAPYCTPEQY KECADPALDF LVEKDQEYCV CEMPCNLTRY 240
GKELSMVKIP SKASAKYLAK KFNKSEQYIG ENILVLDIFF EVLNYETIEQ KKAYEIAGLL 300
GDIGGQMGLF IGASILTVLE LFDYAYEVIK HKLCRRGKCQ KEAKRSSADK GVALSLDDVK 360
RHNPCESLRG HPAGMTYAAN ILPHHPARGT FEDFTC 396 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR004724; EnaC.
 IPR001873; Na+channel_ASC.
 IPR020903; Na+channel_ASC_CS. 
Pfam
 PF00858; ASC 
SMART
  
PROSITE
 PS01206; ASC 
PRINTS
 PR01078; AMINACHANNEL.