CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042769
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase NLK 
Protein Synonyms/Alias
  
Gene Name
 NLK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
321RTACEGAKAHILRGPubiquitination[1]
367PSKRISAKDALAHPYubiquitination[1]
410FEPVTNPKFDDTFEKubiquitination[1]
417KFDDTFEKNLSSVRQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
LHPGSAAAVH PVQQHTSSAA AAAAAAAAAA AMLNPGQQQP YFPSPAPGQA PGPAAAAPAQ 60
VQAAAAATVK AHHHQHSHHP QQQLDIEPDR PIGYGAFGVV WSVTDPRDGK RVALKKMPNV 120
FQNLVSCKRV FRELKMLCFF KHDNVLSALD ILQPPHIDYF EEIYVVTELM QSDLHKIIVS 180
PQPLSSDHVK VFLYQILRGL KYLHSAGILH RDIKPGNLLV NSNCVLKICD FGLARVEELD 240
ESRHMTQEVV TQYYRAPEIL MGSRHYSNAI DIWSVGCIFA ELLGRRILFQ AQSPIQQLDL 300
ITDLLGTPSL EAMRTACEGA KAHILRGPHK QPSLPVLYTL SSQATHEAVH LLCRMLVFDP 360
SKRISAKDAL AHPYLDEGRL RYHTCMCKCC FSTSTGRVYT SDFEPVTNPK FDDTFEKNLS 420
SVRQVKEIIH QFILEQQKGN RVPLCINPQS AAFKSFISST VAQPSEMPPS PLVWE 475 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0004707; F:MAP kinase activity; IEA:Compara.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR003527; MAP_kinase_CS.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS01351; MAPK
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS