UniProt Accession

 ACBP_MOUSE; P31786 

Genbank Protein ID

 X61431; AK018720; AK027906; BC028874 

Genbank Nucleotide ID

 CAA43673.1; BAB31366.1; BAC25658.1; AAH28874.1 

Protein Name

 Acyl-CoA-binding protein 

Protein Synonyms/Alias

 ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP 

Gene Name

 Dbi 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	DKAAEEVKRLKTQPT	ubiquitination	[1]
17	AEEVKRLKTQPTDEE	ubiquitination	[1]
33	LFIYSHFKQATVGDV	ubiquitination	[1]
51	RPGLLDLKGKAKWDS	ubiquitination	[1]
55	LDLKGKAKWDSWNKL	acetylation	[2]
55	LDLKGKAKWDSWNKL	ubiquitination	[1]
61	AKWDSWNKLKGTSKE	ubiquitination	[1]
72	TSKESAMKTYVEKVD	ubiquitination	[1]
77	AMKTYVEKVDELKKK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. 

Sequence Annotation

 DOMAIN 2 87 ACB.
 REGION 29 33 Acyl-CoA binding (By similarity).
 BINDING 14 14 Acyl-CoA (By similarity).
 BINDING 51 51 Acyl-CoA (By similarity).
 BINDING 55 55 Acyl-CoA (By similarity).
 BINDING 74 74 Acyl-CoA (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 29 29 Phosphotyrosine.
 MOD_RES 55 55 N6-acetyllysine; alternate (Probable).
 MOD_RES 55 55 N6-malonyllysine; alternate (By
 MOD_RES 77 77 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Lipid-binding; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 87 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0001942; P:hair follicle development; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0006810; P:transport; IEA:UniProtKB-KW.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.