CPLM-008080

Genbank Nucleotide ID

Phosphatidylinositol transfer protein beta isoform

Protein Synonyms/Alias

PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta

Homo sapiens (Human)

Position	Peptide	Type	References
5	***MVLIKEFRVVLP	acetylation	[1]
5	***MVLIKEFRVVLP	ubiquitination	[2, 3, 4, 5]
44	GEGIEVLKNEPYEKD	ubiquitination	[6]
86	GSLVFHEKAWNAYPY	ubiquitination	[2, 4, 7]
104	IVTNEYMKDDFFIKI	ubiquitination	[2, 4, 6]
110	MKDDFFIKIETWHKP	ubiquitination	[6]
155	QVEPADYKADEDPAL	ubiquitination	[6]
167	PALFQSVKTKRGPLG	ubiquitination	[6]
179	PLGPNWKKELANSPD	ubiquitination	[2, 4]
201	KLVTIKFKWWGLQSK	ubiquitination	[2, 4, 8]
208	KWWGLQSKVENFIQK	ubiquitination	[2, 4, 6]
215	KVENFIQKQEKRIFT	acetylation	[1]
215	KVENFIQKQEKRIFT	ubiquitination	[2, 4, 6, 8]
252	RMEDETQKELETMRK	ubiquitination	[2, 4]

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[7] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR.
Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
[8] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]

Functional Description

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

MOD_RES 215 215 N6-acetyllysine.
MOD_RES 262 262 Phosphoserine (By similarity).

Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Golgi apparatus; Lipid-binding; Phosphoprotein; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0000139; C:Golgi membrane; TAS:Reactome.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome.
GO:0001701; P:in utero embryonic development; IEA:Compara.
GO:0015914; P:phospholipid transport; TAS:Reactome.
GO:0044281; P:small molecule metabolic process; TAS:Reactome.

IPR001666; PI_transfer.
IPR023393; START-like_dom.

PR00391; PITRANSFER.