CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein sens 
Protein Synonyms/Alias
 Protein senseless 
Gene Name
 sens 
Gene Synonyms/Alias
 Lyra; CG32120 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
509CDQSFQRKVDLRRHRsumoylation[1]
Reference
 [1] The SUMO pathway promotes basic helix-loop-helix proneural factor activity via a direct effect on the Zn finger protein senseless.
 Powell LM, Chen A, Huang YC, Wang PY, Kemp SE, Jarman AP.
 Mol Cell Biol. 2012 Jul;32(14):2849-60. [PMID: 22586269] 
Functional Description
 Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination. 
Sequence Annotation
 ZN_FING 413 435 C2H2-type 1.
 ZN_FING 441 463 C2H2-type 2.
 ZN_FING 469 491 C2H2-type 3.
 ZN_FING 497 520 C2H2-type 4.  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Metal-binding; Notch signaling pathway; Nucleus; Reference proteome; Repeat; Sensory transduction; Transcription; Transcription regulation; Vision; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MNHLSPPPSP HSQQPSPAGL GCHGAALDKQ WMQRASAFNT VIASAAAQKL NGRDLPFLYN 60
PLLYSSALLW PQFLLSSATA LGTPLTPMTP KSPASVVLGQ RDRDFALTPE KEHELQMNNN 120
NENSKQDYQE QDEDMPLNLS TKERITSDDS NRDQYHSSSN NSSRSSSSSE VEQLHPMTSL 180
NVTPPPLSAV NLKSSSTPQQ QRQRSQGNII WSPASMCERS ARREQYGLKM EEQGDEEEHQ 240
VDPIVRKFKY ERRTASISSL QSPISSLSAP ASNAVQDLEF EVAQQQLYAH RSAFMAGLTG 300
NNLELLTQHL KLKSEQPQQQ QQQHRIKDEQ QQDNRSAAAL MNLVAAAEFG YMRNQHQQPQ 360
QQQQQQLHHQ QQPQQHQHQQ QHPDSTATDV ARRSSSSSSY QGENEEKRSG RNFQCKQCGK 420
SFKRSSTLST HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT YIHTGEKPHK CTVCLKAFSQ 480
SSNLITHMRK HTGYKPFGCH LCDQSFQRKV DLRRHRESRH EEAPPVEDLK PLKMEVSSSS 540
C 541 
Gene Ontology
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0043425; F:bHLH transcription factor binding; IDA:FlyBase.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:FlyBase.
 GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007411; P:axon guidance; IMP:FlyBase.
 GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.
 GO:0042051; P:compound eye photoreceptor development; IMP:FlyBase.
 GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
 GO:0043066; P:negative regulation of apoptotic process; IMP:FlyBase.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
 GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
 GO:0007422; P:peripheral nervous system development; IMP:FlyBase.
 GO:0008594; P:photoreceptor cell morphogenesis; IMP:FlyBase.
 GO:0045465; P:R8 cell differentiation; NAS:FlyBase.
 GO:0016360; P:sensory organ precursor cell fate determination; IMP:FlyBase.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd.
 IPR001878; Znf_CCHC. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2
 SM00343; ZnF_C2HC 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS