CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sorting nexin-2 
Protein Synonyms/Alias
  
Gene Name
 SNX2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115IAPRIESKSMSAPVIubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 266 AA 
Protein Sequence
MAAEREPPPL GDGKPTDFED LEDGEDLFTS TVSTLESSPS SPEPASLPAE DISANSNGPK 60
PTEVVLDDDR EDLFAATEEV SLDSPEREPI LSSEPSPAVT PVTPTTLIAP RIESKSMSAP 120
VIFDRSREEI EEEANGDIFD IEIGVSDPEK VGDGMNAYMA YRVTTKTSLS MFSKSEFSVK 180
RRFSDFLGLH SKLASKYLHV GYIVPPAPEK SIVGMTKVKV GKEDSSSTEF VEKRRAALER 240
YLQRTVKHPT LLQDPDLRQF LESSEV 266 
Gene Ontology
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR001683; Phox.
 IPR005329; Sorting_nexin_N. 
Pfam
 PF00787; PX
 PF03700; Sorting_nexin 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS