UniProt Accession

 LPXN_HUMAN; O60711; B2R8B4; B4DV71; Q53FW6; Q6FI07 

Genbank Protein ID

 AF062075; AK300955; AK313306; CR536531; AK223165; AP001350; AP003557; CH471076; BC019035 

Genbank Nucleotide ID

 AAC16014.1; BAG62583.1; BAG36111.1; CAG38768.1; BAD96885.1; EAW73808.1; AAH19035.1 

Protein Name

 Leupaxin 

Protein Synonyms/Alias

  

Gene Name

 LPXN 

Gene Synonyms/Alias

 LDLP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
265	DKKPYCRKDFLAMFS	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. 

Sequence Annotation

 DOMAIN 150 208 LIM zinc-binding 1.
 DOMAIN 209 267 LIM zinc-binding 2.
 DOMAIN 268 326 LIM zinc-binding 3.
 DOMAIN 327 386 LIM zinc-binding 4.
 MOTIF 3 15 LD motif 1.
 MOTIF 70 82 LD motif 2.
 MOTIF 92 103 LD motif 3.
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 22 22 Phosphotyrosine.
 MOD_RES 62 62 Phosphotyrosine.
 MOD_RES 72 72 Phosphotyrosine; by LYN.  

Keyword

 3D-structure; Activator; Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; LIM domain; Membrane; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005925; C:focal adhesion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0002102; C:podosome; IDA:UniProtKB.
 GO:0003712; F:transcription cofactor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0050859; P:negative regulation of B cell receptor signaling pathway; IDA:UniProtKB.
 GO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB.
 GO:0006461; P:protein complex assembly; TAS:ProtInc.
 GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017305; Leupaxin.
 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS