CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027137
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKIAA1027 protein 
Protein Synonyms/Alias
  
Gene Name
 Tln1 
Gene Synonyms/Alias
 mKIAA1027 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
38ISIGNVVKTMQFEPSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2564 AA 
Protein Sequence
RAQGGAQSRA AQVSPGRRAE AATMVALSLK ISIGNVVKTM QFEPSTMVYD ACRMIRERIP 60
EALAGPPNDF GLFLSDDDPK KGIWLEAGKA LDYYMLRNGD TMEYRKKQRP LKIRMLDGTV 120
KTIMVDDSKT VTDMLMTICA RIGITNHDEY SLVRELMEEK KDEGTGTLRK DKTLLRDEKK 180
MEKLKQKLHT DDELNWLDHG RTLREQGVEE HETLLLRRKF FYSDQNVDSR DPVQLNLLYV 240
QARDDILNGS HPVSFDKACE FAGFQCQIQF GPHNEQKHKA GFLDLKDFLP KEYVKQKGER 300
KIFQAHKNCG QMSEIEAKVR YVKLARSLKT YGVSFFLVKE KMKGKNKLVP RLLGITKECV 360
MRVDEKTKEV IQEWSLTNIK RWAASPKSFT LDFGDYQDGY YSVQTTEGEQ IAQLIAGYID 420
IILKKKKSKD HFGLEGDEES TMLEDSVSPK KSTVLQQQYN RVGKVEHGSV ALPAIMRSGA 480
SGPENFQVGS MPPAQQQITS GQMHRGHMPP LTSAQQALTG TINSSMQAVQ AAQATLDDFE 540
TLPPLGQDAA SKAWRKNKMD ESKHEIHSQV DAITAGTASV VNLTAGDPAE TDYTAVGCAV 600
TTISSNLTEM SRGVKLLAAL LEDEGGNGRP LLQAAKGLAG AVSELLRSAQ PASAEPRQNL 660
LQAAGNVGQA SGELLQQIGE SDTDPHFQDV LMQLAKAVAS AAAALVLKAK SVAQRTEDSG 720
LQTQVIAAAT QCALSTSQLV ACTKVVAPTI SSPVCQEQLV EAGRLVAKAV EGCVSASQAA 780
TEDGQLLRGV GAAATAVTQA LNELLQHVKA HATGAGPAGR YDQATDTILT VTENIFSSMG 840
DAGEMVRQAR ILAQATSDLV NAIKADAEGE SDLENSRKLL SAAKILADAT AKMVEAAKGA 900
AAHPDSEEQQ QRLREAAEGL RMATNAAAQN AIKKKLVQRL EHAAKQAAAS ATQTIAAAQH 960
AASAPKASAG PQPLLVQSCK AVAEQIPLLV QGVRGSQAQP DSPSAQLALI AASQSFLQPG 1020
GKMVAAAKAS VPTIQDQASA MQLSQCAKNL GTALAELRTA AQKAQEACGP LEMDSALSVV 1080
QNLEKDLQEI KAAARDGKLK PLPGETMEKC TQDLGNSTKA VSSAIAKLLG EIAQGNENYA 1140
GIAARDVAGG LRSLAQAARG VAALTSDPAV QAIVLDTASD VLDKASSLIE EAKKASGHPG 1200
DPESQQRLAQ VAKAVTQALN RCVSCLPGQR DVDNALRAVG DASKRLLSDS LPPSTGTFQE 1260
AQSRLNEAAA GLNQAATELV QASRGTPQDL ARASGRFGQD FSTFLEAGVE MAGQAPSQED 1320
RAQVVSILKG ISMSSSKLLL AAKALSTDPA SPNLKSQLAA AARAVTDSIN QLITMCTQQA 1380
PGQKECDNAL RQLETVRELL ENPVQPINDM SYFGCLDSVM ENSKVLGEAM TGISQNAKNG 1440
NLPEFGDAIA TASKALCGFT EAAAQAAYLV GVSDPNSQAG QQGLVEPTQF ARANQAIQMA 1500
CQSLGEPGCT QAQVLSAATI VAKHTSALCN SCRLASARTA NPTAKRQFVQ SAKEVANSTA 1560
NLVKTIKALD GDFTEENRAQ CRAATAPLLE AVDNLSAFAS NPEFSSVPAQ ISPEGRAAME 1620
PIVISAKTML ESAGGLIQTA RALAVNPRDP PRWSVLAGHS RTVSDSIKKL ITSMRDKAPG 1680
QLECETAIAA LNSCLRDLDQ ASLAAVSQQL APREGISQEA LHTQMLTAVQ EISHLIEPLA 1740
SAARAEASQL GHKVSQMAQY FEPLTLAAVG AASKTLSHPQ QMALLDQTKT LAESALQLLY 1800
TAKEAGGNPK QAAHTQEALE EAVQMMTEAV EDLTTTLNEA ASAAGVVGGM VDSITQAINQ 1860
LDEGPMGDPE GSFVDYQTTM VRTAKAIAVT VQEMVTKSNT SPEELGPLAN QLTSDYGRLA 1920
SQAKPAAVAA ENEEIGAHIK HRVQELGHGC SALVTKAGAL QCSPSDVYTK KELIECARRV 1980
SEKVSHVLAA LQAGNRGTQA CITAASAVSG IIADLDTTIM FATAGTLNRE GAETFADHRE 2040
GILKTAKVLV EDTKVLVQNA AGSQEKLAQA AQSSVATITR LADVVKLGAA SLGAEDPETQ 2100
VVLINAVKDV AKALGDLISA TKAAAGKVGD DPAVWQLKNS AKVMVTNVTS LLKTVKAVED 2160
EATKGTRALE ATTEHIRQEL AVFCSPEPPA KTSTPEDFIR MTKGITMATA KAVAAGNSCR 2220
QEDVIATANL SRRAIADMLR ACKEAAFHPE VAPDVRLRAL HYGRECANGY LELLDHVLLT 2280
LQKPNPDLKQ QLTGHSKRVA GSVTELIQAA EAMKGTEWVD PEDPTVIAEN ELLGAAAAIE 2340
AAAKKLEQLK PRAKPKEADE SLNFEEQILE AAKSIAAATS ALVKAASAAQ RELVAQGKVG 2400
AIPANALDDG QWSQGLISAA RMVAAATNNL CEAANAAVQG HASQEKLISS AKQVAASTAQ 2460
LLVACKVKAD QDSEAMKRLQ AAGNAVKRAS DNLVKAAQKA AAFEDQENET VVVKEKMVGG 2520
IAQIIAAQEE MLRKERELEE ARKKFAQIRQ QQYKFLPSEL RDEH 2564 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0001726; C:ruffle; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0007044; P:cell-substrate junction assembly; IMP:MGI.
 GO:0030866; P:cortical actin cytoskeleton organization; IMP:MGI.
 GO:0007016; P:cytoskeletal anchoring at plasma membrane; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR002558; ILWEQ_dom.
 IPR002404; Insln_rcpt_S1.
 IPR011993; PH_like_dom.
 IPR015710; Talin-1.
 IPR015224; Talin_cent.
 IPR015009; Vinculin-bd_dom.
 IPR006077; Vinculin/catenin. 
Pfam
 PF00373; FERM_M
 PF09379; FERM_N
 PF01608; I_LWEQ
 PF02174; IRS
 PF09141; Talin_middle
 PF08913; VBS 
SMART
 SM00295; B41
 SM00307; ILWEQ 
PROSITE
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3
 PS50945; I_LWEQ 
PRINTS