CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014890
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenosine deaminase-like protein 
Protein Synonyms/Alias
  
Gene Name
 ADAL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
157RGGPLVAKETVKLAEubiquitination[1]
200EPLLEAKKAGLKLALubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity). 
Sequence Annotation
 ACT_SITE 211 211 Proton donor (By similarity).
 METAL 24 24 Zinc; catalytic (By similarity).
 METAL 26 26 Zinc; catalytic (By similarity).
 METAL 208 208 Zinc; catalytic (By similarity).
 METAL 293 293 Zinc; catalytic (By similarity).
 BINDING 26 26 Substrate (By similarity).
 BINDING 181 181 Substrate; via amide nitrogen and
 BINDING 294 294 Substrate (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Nucleotide metabolism; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 355 AA 
Protein Sequence
MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD QMTVIDKGKK 60
RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK YLELRSTPRR ENATGMTKKT 120
YVESILEGIK QSKQENLDID VRYLIAVDRR GGPLVAKETV KLAEEFFLST EGTVLGLDLS 180
GDPTVGQAKD FLEPLLEAKK AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE 240
GGSLDLVDFV RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT 300
HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP RVLHI 355 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004000; F:adenosine deaminase activity; EXP:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006154; P:adenosine catabolic process; IBA:RefGenome.
 GO:0017144; P:drug metabolic process; TAS:Reactome.
 GO:0046103; P:inosine biosynthetic process; IBA:RefGenome.
 GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
 GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome.
 GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
 GO:0043101; P:purine-containing compound salvage; TAS:Reactome. 
Interpro
 IPR001365; A/AMP_deaminase_dom. 
Pfam
 PF00962; A_deaminase 
SMART
  
PROSITE
 PS00485; A_DEAMINASE 
PRINTS