UniProt Accession

 HMGN1_MOUSE; P18608; Q5HZY9 

Genbank Protein ID

 X53476; BC083138; BC088834 

Genbank Nucleotide ID

 CAA37569.1; AAH83138.1; AAH88834.1 

Protein Name

 Non-histone chromosomal protein HMG-14 

Protein Synonyms/Alias

 High mobility group nucleosome-binding domain-containing protein 1 

Gene Name

 Hmgn1 

Gene Synonyms/Alias

 Hmg-14; Hmg14 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	VSADGAAKAEPKRRS	acetylation	[1, 2, 3]
26	RSARLSAKPAPAKVD	acetylation	[3]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2. 

Sequence Annotation

 MOD_RES 7 7 Phosphoserine; by RPS6KA5.
 MOD_RES 13 13 N6-acetyllysine (By similarity).
 MOD_RES 20 20 Phosphoserine; by RPS6KA5.
 MOD_RES 24 24 Phosphoserine; by RPS6KA5.
 MOD_RES 80 80 Phosphothreonine.
 MOD_RES 84 84 Phosphoserine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 95 95 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 96 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:InterPro.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
 GO:0006325; P:chromatin organization; IMP:MGI.
 GO:0048597; P:post-embryonic camera-type eye morphogenesis; IMP:MGI.
 GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:MGI.
 GO:0040034; P:regulation of development, heterochronic; IGI:MGI.
 GO:0050678; P:regulation of epithelial cell proliferation; IMP:MGI.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0010224; P:response to UV-B; IMP:MGI.
 GO:0010225; P:response to UV-C; IDA:MGI.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:MGI. 

Interpro

 IPR000079; HMGN_fam. 

Pfam

 PF01101; HMG14_17 

SMART

 SM00527; HMG17 

PROSITE

 PS00355; HMG14_17 

PRINTS

 PR00925; NONHISHMG17.