| Tag | Content |
|---|
| CPLM ID | CPLM-005372 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
Protein Synonyms/Alias | E-NPP 1; Alkaline phosphodiesterase 1; Nucleotide pyrophosphatase; NPPase |
Gene Name | NPP1 |
Gene Synonyms/Alias | YCR026C; YCR246; YCR26C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 66 | PIVIGDAKDSRDGSN | ubiquitination | [1] | | 137 | ILMINIAKPHHSTRV | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5. |
Sequence Annotation | REGION 168 545 Phosphodiesterase.
ACT_SITE 219 219 By similarity.
CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
CARBOHYD 204 204 N-linked (GlcNAc...) (Potential).
CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
CARBOHYD 296 296 N-linked (GlcNAc...) (Potential).
CARBOHYD 403 403 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Hydrolase; Membrane; Multifunctional enzyme; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 742 AA |
Protein Sequence | MELQNDLESL DNELNDFSED PFRDDFITDE DAVRSGWRSA WTRMKYWFYK NRLKWTNNPI 60
VIGDAKDSRD GSNFRRGIPL YELDANGQPI DTELVDENEL SFGTGFHSKV PFKIIFRTLF 120
GSLVFAIFLI LMINIAKPHH STRVLSHFGS PEFDPYVKYF NGTHEFFPLT IVISLDGFHP 180
SLISKRNTPF LHDLYELKYD GGMNITSTPF MVPSFPTETF PNHWTLVTGQ YPIHHGIVSN 240
VFWDPDLNEE FHPGVLDPRI WNNNDTEPIW QTVQSAFDGD IPFKAATHMW PGSDVNYTKY 300
NEEKLQPEHK NPIARERTPF YFDEFNAKEP LSQKLSKIIE YVDMSTLNER PQLILGYVPN 360
VDAFGHKHGY PSESEYYYED FTETLGEVDT FLKQLVESLQ ERNLTSFTNL VIVSDHGMSD 420
IVVPSNVIIW EDLLDEKLRK DYVSHAYLEG PMMAISLKDS GNINEVYHNL KTSIDEDKYT 480
VYVNGNFPKE WNFNDGKNHH MASIWIVPEP GYAVMKKEQL KKVAKGDHKD KNEDNVFTIG 540
SHGYDNNAID MRSVFIGMGP YFPQGYIEPF QNTEIYNLLC DICGVAEKDR NSNDGTGMLM 600
NQLREPQSSE EVEIEDDFDY LVSKFGEFST YNIIWGGYPE ETEQDNVDND NDDNDDGNTD 660
EIAAMPSSSL TIKLEMTTSI PSATETLLGE TSPSSRSSSS SSIQASATAS TVGDWLQDII 720
NDAKDLIDDI IDSIDDLVDS DT 742 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0035529; F:NADH pyrophosphatase activity; IEA:EC. GO:0017111; F:nucleoside-triphosphatase activity; IMP:SGD. GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IMP:SGD. GO:0004551; F:nucleotide diphosphatase activity; ISS:SGD. GO:0004528; F:phosphodiesterase I activity; ISS:SGD. GO:0016036; P:cellular response to phosphate starvation; IEP:SGD. GO:0009141; P:nucleoside triphosphate metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |