UniProt Accession

 G5E959_HUMAN; G5E959 

Genbank Protein ID

 AC100835; CH471136 

Genbank Nucleotide ID

 EAW99325.1 

Protein Name

 CDC-like kinase 3, isoform CRA_d 

Protein Synonyms/Alias

 Dual-specificity protein kinase CLK3 

Gene Name

 CLK3 

Gene Synonyms/Alias

 hCG_1739025 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
140	SRSVEDDKEGHLVCR	ubiquitination	[1]
163	WKSQVALKIIRNVGK	ubiquitination	[1]
183	RLEINVLKKIKEKDK	ubiquitination	[1]
225	KNTFEFLKENNFQPY	ubiquitination	[1, 2]
262	QLTHTDLKPENILFV	ubiquitination	[2]
382	IHRTRKQKYFYKGGL	ubiquitination	[1]
386	RKQKYFYKGGLVWDE	ubiquitination	[1, 2, 3]
406	RYVKENCKPLKSYML	ubiquitination	[1, 2]
409	KENCKPLKSYMLQDS	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS