CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Endoribonuclease Dicer 
Protein Synonyms/Alias
  
Gene Name
 Dicer1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
642PFTHLAPKCRTRELPubiquitination[1]
1452GSGAFVRKISLSPFSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1906 AA 
Protein Sequence
MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT IVCLNTGSGK 60
TFIAVLLTKE LAHQIRGDLN PHAKRTVFLV NSANQVAQQV SAVRTHSDLK VGEYSDLEVN 120
ASWTKERWSQ EFTKHQVLIM TCYVALTVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM 180
KLCESCPSCP RILGLTASIL NGKCDPEELE EKIQKLERIL RSDAETATDL VVLDRYTSQP 240
CEIVVDCGPF TDRSGLYERL LMELEAALDF INDCNVAVHS KERDSTLISK QILSDCRAVL 300
VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT LLRKIHALCE EYFSPASLDL 360
KYVTPKVMKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDD DEEIEEKEKP 420
ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR 480
SKQMEAEFRK QEEVLRKFRA HETNLLIATS VVEEGVDIPK CNLVVRFDLP TEYRSYVQSK 540
GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSADGAEAD VHAGVDDEDA 600
FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD GTFYSTLYLP 660
INSPLRASIV GPPMDSVRLA ERVVALICCE KLHKIGELDE HLMPVGKETV KYEEELDLHD 720
EEETSVPGRP GSTKRRQCYP KAIPECLRES YPKPDQPCYL YVIGMVLTTP LPDELNFRRR 780
KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSQ QMLELITRLH 840
QYIFSHILRL EKPALEFKPT GAESAYCVLP LNVVNDSGTL DIDFKFMEDI EKSEARIGIP 900
STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF PSPEYETFAE 960
YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR KAKWESLQNK 1020
QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPVDFR 1080
YPNLDFGWKK SIDSKSFISS CNSSLAESDN YCKHSTTVVP EHAAHQGATR PSLENHDQMS 1140
VNCKRLPAES PAKLQSEVST DLTAINGLSY NKNLANGSYD LVNRDFCQGN QLNYFKQEIP 1200
VQPTTSYPIQ NLYNYENQPK PSNECPLLSN TYLDGNANTS TSDGSPAVST MPAMMNAVKA 1260
LKDRMDSEQS PSVGYSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD SFLKHAITTY 1320
LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD 1380
KSNSEKWEKD EMTKDCLLAN GKLGEACEEE EDLTWRAPKE EAEDEDDFLE YDQEHIQFID 1440
SMLMGSGAFV RKISLSPFSA SDSAYEWKMP KKASLGSMPF ASGLEDFDYS SWDAMCYLDP 1500
SKAVEEDDFV VGFWNPSEEN CGVDTGKQSI SYDLHTEQCI ADKSIADCVE ALLGCYLTSC 1560
GERAAQLFLC SLGLKVLPVI KRTSREKALD PAQENGSSQQ KSLSGSCASP VGPRSSAGKD 1620
LEYGCLKIPP RCMFDHPDAE KTLNHLISGF ETFEKKINYR FKNKAYLLQA FTHASYHYNT 1680
ITDCYQRLEF LGDAILDYLI TKHLYEDPRQ HSPGVLTDLR SALVNNTIFA SLAVKYDYHK 1740
YFKAVSPELF HVIDDFVKFQ LEKNEMQGMD SELRRSEEDE EKEEDIEVPK AMGDIFESLA 1800
GAIYMDSGMS LEVVWQVYYP MMQPLIEKFS ANVPRSPVRE LLEMEPETAK FSPAERTYDG 1860
KVRVTVEVVG KGKFKGVGRS YRIAKSAAAR RALRSLKANQ PQVPNS 1906 
Gene Ontology
 GO:0016442; C:RNA-induced silencing complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003725; F:double-stranded RNA binding; IEA:Compara.
 GO:0035198; F:miRNA binding; IDA:MGI.
 GO:0004525; F:ribonuclease III activity; IDA:MGI.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:MGI.
 GO:0055013; P:cardiac muscle cell development; IMP:MGI.
 GO:0021987; P:cerebral cortex development; IMP:MGI.
 GO:0051607; P:defense response to virus; IMP:MGI.
 GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
 GO:0071335; P:hair follicle cell proliferation; IMP:MGI.
 GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
 GO:0060119; P:inner ear receptor cell development; IMP:MGI.
 GO:0060576; P:intestinal epithelial cell development; IGI:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0021889; P:olfactory bulb interneuron differentiation; IMP:MGI.
 GO:2000630; P:positive regulation of miRNA metabolic process; IMP:MGI.
 GO:0031643; P:positive regulation of myelination; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0031054; P:pre-miRNA processing; IDA:MGI.
 GO:0030422; P:production of siRNA involved in RNA interference; IDA:MGI.
 GO:0051726; P:regulation of cell cycle; IMP:MGI.
 GO:0070173; P:regulation of enamel mineralization; IMP:MGI.
 GO:0045664; P:regulation of neuron differentiation; IMP:MGI.
 GO:0048713; P:regulation of oligodendrocyte differentiation; IMP:MGI.
 GO:0045069; P:regulation of viral genome replication; IMP:MGI.
 GO:0016075; P:rRNA catabolic process; IEA:InterPro.
 GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
 GO:0051225; P:spindle assembly; IMP:MGI.
 GO:0048536; P:spleen development; IMP:MGI.
 GO:0019827; P:stem cell maintenance; IMP:MGI.
 GO:0030423; P:targeting of mRNA for destruction involved in RNA interference; IEA:Compara.
 GO:0010070; P:zygote asymmetric cell division; IMP:MGI. 
Interpro
 IPR005034; Dicer_dsRNA_binding_fold.
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR003100; PAZ.
 IPR011907; RNase_III.
 IPR000999; RNase_III_dom. 
Pfam
 PF00270; DEAD
 PF03368; dsRNA_bind
 PF00271; Helicase_C
 PF02170; PAZ
 PF00636; Ribonuclease_3 
SMART
 SM00487; DEXDc
 SM00358; DSRM
 SM00490; HELICc
 SM00949; PAZ
 SM00535; RIBOc 
PROSITE
 PS51327; DICER_DSRBF
 PS50137; DS_RBD
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS50821; PAZ
 PS00517; RNASE_3_1
 PS50142; RNASE_3_2 
PRINTS