CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012146
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polycystin-2 
Protein Synonyms/Alias
 Autosomal dominant polycystic kidney disease type II protein; Polycystic kidney disease 2 protein; Polycystwin; R48321 
Gene Name
 PKD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
695KSDLAQQKAEMELSDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). Functions as a calcium permeable cation channel. 
Sequence Annotation
 DOMAIN 750 785 EF-hand.
 REGION 704 794 EF-hand domain.
 REGION 803 822 Linker.
 REGION 828 968 C-terminal coiled coil domain.
 MOTIF 316 328 Polycystin motif.
 MOD_RES 812 812 Phosphoserine.
 CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
 CARBOHYD 305 305 N-linked (GlcNAc...) (Potential).
 CARBOHYD 328 328 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).
 CARBOHYD 375 375 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative splicing; Calcium; Cell projection; Ciliopathy; Cilium; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Glycoprotein; Ion channel; Ion transport; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 968 AA 
Protein Sequence
MVNSSRVQPQ QPGDAKRPPA PRAPDPGRLM AGCAAVGASL AAPGGLCEQR GLEIEMQRIR 60
QAAARDPPAG AAASPSPPLS SCSRQAWSRD NPGFEAEEEE EEVEGEEGGM VVEMDVEWRP 120
GSRRSAASSA VSSVGARSRG LGGYHGAGHP SGRRRRREDQ GPPCPSPVGG GDPLHRHLPL 180
EGQPPRVAWA ERLVRGLRGL WGTRLMEESS TNREKYLKSV LRELVTYLLF LIVLCILTYG 240
MMSSNVYYYT RMMSQLFLDT PVSKTEKTNF KTLSSMEDFW KFTEGSLLDG LYWKMQPSNQ 300
TEADNRSFIF YENLLLGVPR IRQLRVRNGS CSIPQDLRDE IKECYDVYSV SSEDRAPFGP 360
RNGTAWIYTS EKDLNGSSHW GIIATYSGAG YYLDLSRTRE ETAAQVASLK KNVWLDRGTR 420
ATFIDFSVYN ANINLFCVVR LLVEFPATGG VIPSWQFQPL KLIRYVTTFD FFLAACEIIF 480
CFFIFYYVVE EILEIRIHKL HYFRSFWNCL DVVIVVLSVV AIGINIYRTS NVEVLLQFLE 540
DQNTFPNFEH LAYWQIQFNN IAAVTVFFVW IKLFKFINFN RTMSQLSTTM SRCAKDLFGF 600
AIMFFIIFLA YAQLAYLVFG TQVDDFSTFQ ECIFTQFRII LGDINFAEIE EANRVLGPIY 660
FTTFVFFMFF ILLNMFLAII NDTYSEVKSD LAQQKAEMEL SDLIRKGYHK ALVKLKLKKN 720
TVDDISESLR QGGGKLNFDE LRQDLKGKGH TDAEIEAIFT KYDQDGDQEL TEHEHQQMRD 780
DLEKEREDLD LDHSSLPRPM SSRSFPRSLD DSEEDDDEDS GHSSRRRGSI SSGVSYEEFQ 840
VLVRRVDRME HSIGSIVSKI DAVIVKLEIM ERAKLKRREV LGRLLDGVAE DERLGRDSEI 900
HREQMERLVR EELERWESDD AASQISHGLG TPVGLNGQPR PRSSRPSSSQ STEGMEGAGG 960
NGSSNVHV 968 
Gene Ontology
 GO:0045180; C:basal cortex; IDA:BHF-UCL.
 GO:0009925; C:basal plasma membrane; IDA:BHF-UCL.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0071458; C:integral to cytosolic side of endoplasmic reticulum membrane; IDA:BHF-UCL.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; IDA:BHF-UCL.
 GO:0005887; C:integral to plasma membrane; IDA:BHF-UCL.
 GO:0030027; C:lamellipodium; IDA:BHF-UCL.
 GO:0005932; C:microtubule basal body; IDA:MGI.
 GO:0072686; C:mitotic spindle; IDA:BHF-UCL.
 GO:0031512; C:motile primary cilium; ISS:BHF-UCL.
 GO:0031513; C:nonmotile primary cilium; ISS:BHF-UCL.
 GO:0002133; C:polycystin complex; ISS:BHF-UCL.
 GO:0042805; F:actinin binding; IDA:BHF-UCL.
 GO:0051117; F:ATPase binding; ISS:BHF-UCL.
 GO:0005509; F:calcium ion binding; ISS:BHF-UCL.
 GO:0048763; F:calcium-induced calcium release activity; IDA:BHF-UCL.
 GO:0005267; F:potassium channel activity; ISS:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0005245; F:voltage-gated calcium channel activity; IDA:BHF-UCL.
 GO:0005248; F:voltage-gated sodium channel activity; IDA:BHF-UCL.
 GO:0035904; P:aorta development; IEP:UniProtKB.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEP:UniProtKB.
 GO:0007050; P:cell cycle arrest; ISS:BHF-UCL.
 GO:0071498; P:cellular response to fluid shear stress; IMP:BHF-UCL.
 GO:0071464; P:cellular response to hydrostatic pressure; IDA:BHF-UCL.
 GO:0071470; P:cellular response to osmotic stress; IDA:BHF-UCL.
 GO:0034614; P:cellular response to reactive oxygen species; NAS:BHF-UCL.
 GO:0051298; P:centrosome duplication; NAS:BHF-UCL.
 GO:0042994; P:cytoplasmic sequestering of transcription factor; IMP:BHF-UCL.
 GO:0050982; P:detection of mechanical stimulus; ISS:BHF-UCL.
 GO:0003127; P:detection of nodal flow; ISS:BHF-UCL.
 GO:0071910; P:determination of liver left/right asymmetry; IMP:BHF-UCL.
 GO:0001892; P:embryonic placenta development; ISS:BHF-UCL.
 GO:0001947; P:heart looping; IMP:BHF-UCL.
 GO:0007259; P:JAK-STAT cascade; ISS:BHF-UCL.
 GO:0072177; P:mesonephric duct development; IEP:UniProtKB.
 GO:0072218; P:metanephric ascending thin limb development; IEP:UniProtKB.
 GO:0072214; P:metanephric cortex development; IEP:UniProtKB.
 GO:0072219; P:metanephric cortical collecting duct development; IEP:UniProtKB.
 GO:0072235; P:metanephric distal tubule development; IEP:UniProtKB.
 GO:0072075; P:metanephric mesenchyme development; IEP:UniProtKB.
 GO:0035502; P:metanephric part of ureteric bud development; IEP:UniProtKB.
 GO:0072284; P:metanephric S-shaped body morphogenesis; IEP:UniProtKB.
 GO:0072208; P:metanephric smooth muscle tissue development; IEP:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; NAS:BHF-UCL.
 GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IMP:BHF-UCL.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; ISS:BHF-UCL.
 GO:0021915; P:neural tube development; IEP:UniProtKB.
 GO:0060674; P:placenta blood vessel development; ISS:BHF-UCL.
 GO:0071158; P:positive regulation of cell cycle arrest; IMP:BHF-UCL.
 GO:0031659; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle; IDA:BHF-UCL.
 GO:0031587; P:positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IMP:BHF-UCL.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0090279; P:regulation of calcium ion import; IDA:BHF-UCL.
 GO:0030814; P:regulation of cAMP metabolic process; ISS:BHF-UCL.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
 GO:0061441; P:renal artery morphogenesis; IEP:UniProtKB.
 GO:0061333; P:renal tubule morphogenesis; ISS:BHF-UCL.
 GO:0021510; P:spinal cord development; IEP:UniProtKB. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR013122; PKD1_2_channel.
 IPR003915; PKD_2. 
Pfam
 PF08016; PKD_channel 
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS
 PR01433; POLYCYSTIN2.